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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제1호
- 발행연도
- 2017.1
- 수록면
- 83 - 90 (8page)
이용수
초록· 키워드
오류제보하기
Advanced age is one of the risk factors for vascular diseases that are mainly caused by impaired nitric oxide (NO) production. It has been demonstrated that endothelial arginase constrains the activity of endothelial nitric oxide synthase (eNOS) and limits NO generation. Hence, arginase inhibition is suggested to be vasoprotective in aging. In this study, we examined the effects of intravenous injection of Piceatannol, an arginase inhibitor, on aged mice. Our results show that Piceatannol administration reduced the blood pressure in aged mice by inhibiting arginase activity, which was associated with NO production and reactive oxygen species generation. In addition, Piceatannol administration recovered Ca2+/ calmodulin-dependent protein kinase II phosphorylation, eNOS phosphorylation and eNOS dimer stability in the aged mice. The improved NO signaling was shown to be effective in attenuating the phenylephrine-dependent contractile response and in enhancing the acetylcholine-dependent vasorelaxation response in aortic rings from the aged mice. These data suggest Piceatannol as a potential treatment for vascular disease.
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등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Seals DR / 2011 / Aging and vascular endothelial function in humans / Clin Sci(Lond) 120:357~375
Berkowitz DE / 2003 / Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels / Circulation 108:2000~2006
Katusic ZS / 2007 / Mechanisms of endothelial dysfunction induced by aging : role of arginase I / Circ Res 101:640~641
Nisoli E / 2004 / Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals / Proc Natl Acad Sci U S A 101:16507~16512
Moncada S / 1993 / The L-arginine-nitric oxide pathway / N Engl J Med 329:2002~2012
Berkowitz DE / 2003 / Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels / Circulation 108:2000~2006
Katusic ZS / 2007 / Mechanisms of endothelial dysfunction induced by aging : role of arginase I / Circ Res 101:640~641
Nisoli E / 2004 / Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals / Proc Natl Acad Sci U S A 101:16507~16512
Moncada S / 1993 / The L-arginine-nitric oxide pathway / N Engl J Med 329:2002~2012
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