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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 764 - 778 (15page)
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Purpose The purpose of this study was to identify the concordant or discordant genomic profiling between primary and matched metastatic tumors in patients with colorectal cancer (CRC) and to explore the clinical implication. Materials and Methods Surgical samples of primary and matched metastatic tissues from 158 patients (335 samples) with CRC at Korea University Anam Hospital were evaluated using the Ion AmpliSeq Cancer Hotspot Panel. We compared genetic variants and classified them as concordant, primary-specific, and metastasis-specific variants. We used a combination of principal components analysis and clustering to find genomic groups. Kaplan-Meier curves were used to appraise survival between genomic groups. We used machine learning to confirm the correlation between genetic variants and metastatic sites. Results A total of 282 types of deleterious non-synonymous variants were selected for analysis. Of a total of 897 variants, an average of 40% was discordant. Three genomic groups were yielded based on the genomic discrepancy patterns. Overall survival differed significantly between the genomic groups. The poorest group had the highest proportion of concordant KRAS G12V and additional metastasis-specific SMAD4. Correlation analysis between genetic variants and metastatic sites suggested that concordant KRAS mutations would have more disseminated metastases. Conclusion Driver gene mutations were mostly concordant; however, discordant or metastasis-specific mutations were present. Clinically, the concordant driver genetic changes with additional metastasis-specific variants can predict poor prognosis for patients with CRC.
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참고문헌 (30)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Riihimaki M / 2012 / Colorectal cancer patients: what do they die of? / Frontline Gastroenterol 3:143~149
Hellman S / 1995 / Oligometastases / J Clin Oncol 13:8~10
Weichselbaum RR / 2011 / Oligometastases revisited / Nat Rev Clin Oncol 8:378~382
Andres A / 2015 / Surgical management of patients with colorectal cancer and simultaneous liver and lung metastases / Br J Surg 102:691~699
Riihimaki M / 2012 / Colorectal cancer patients: what do they die of? / Frontline Gastroenterol 3:143~149
Hellman S / 1995 / Oligometastases / J Clin Oncol 13:8~10
Weichselbaum RR / 2011 / Oligometastases revisited / Nat Rev Clin Oncol 8:378~382
Andres A / 2015 / Surgical management of patients with colorectal cancer and simultaneous liver and lung metastases / Br J Surg 102:691~699
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