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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 161 - 167 (7page)
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Purpose Although the mutation status of KRAS is highly concordant in primary and metastatic lesions, it has not been generalized to other major pathway genes.
Materials and Methods In this study, 41 genes were evaluated and the mutational profiles were compared in 46 colorectal cancer patients with paired surgical specimens of primary and metastatic lesions: synchronous (n=27) and metachronous (n=19) lesions. A high-throughput mass spectrometry- based genotyping platform validated by orthogonal chemistry, OncoMap v.4.4, was used to evaluate the formalin-fixed, paraffin-embedded surgical specimens. The patients’ demographics, tumor characteristics, and microsatellite instability status were analyzed by a retrospective chart review.
Results In this study, with OncoMap, mutations were identified in 80.4% of patients with the following frequency: KRAS (39.1%), TP53 (28.3%), APC (28.3%), PIK3CA (6.5%), BRAF (6.5%), and NRAS (4.3%). Although 19.6% (9/46) of the patients showed no gene mutations, 43.5% (20/46) and 37.0% (17/46) had mutations in one and two or more genes, respectively.
The synchronous and metachronous lesions showed similar mutational profiles. Paired samples between primary and metastatic tumors differed in 7.4% (2/27) and 10.5% (2/19) for synchronous and metachronous according to OncoMap.
Conclusion These findings indicate the major pathway genes, including KRAS, TP53, APC, PIK3CA, BRAF, and NRAS, are often concordant between the primary and metastatic lesions regardless of the temporal relationship of metastasis.
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참고문헌 (18)
참고문헌 신청
Brannon AR / 2014 / Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions / Genome Biol 15 : 454
Chu J / 2013 / Natural history and outcomes of synchronous and metachronous colorectal cancers (CRC):a population-based analysis / J Clin Oncol 31 (Suppl)
El Zouhairi M / 2011 / Molecularly targeted therapy for metastatic colon cancer : proven treatments and promising new agents / Gastrointest Cancer Res 4 : 15 ~ 21
Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group / 2013 / Recommendations from the EGAPP Working Group: can testing of tumor tissue for mut
Gerlinger M / 2012 / Intratumor heterogeneity and branched evolution revealed by multiregion sequencing / N Engl J Med 366 : 883 ~ 892
Chu J / 2013 / Natural history and outcomes of synchronous and metachronous colorectal cancers (CRC):a population-based analysis / J Clin Oncol 31 (Suppl)
El Zouhairi M / 2011 / Molecularly targeted therapy for metastatic colon cancer : proven treatments and promising new agents / Gastrointest Cancer Res 4 : 15 ~ 21
Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group / 2013 / Recommendations from the EGAPP Working Group: can testing of tumor tissue for mut
Gerlinger M / 2012 / Intratumor heterogeneity and branched evolution revealed by multiregion sequencing / N Engl J Med 366 : 883 ~ 892
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