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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 19 - 30 (12page)
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Purpose: Steroid 5-alpha reductase type 2 (SRD5A2) modifies testosterone to dihydrotestosterone (DHT) in the prostate. Singlenucleotidepolymorphisms (SNPs) of the SRD5A2 gene might affect DHT. We sought to understand the relationship of SRD5A2SNPs to prostate cancer in the Korean population.
Materials and Methods: Twenty-six common SNPs in the SRD5A2 gene were assessed in 272 prostate cancer cases and 173 controls.
Single-locus analyses were conducted by using conditional logistic regression. Additionally, we performed a haplotype analysisfor the SRD5A2 SNPs tested.
Results: Among the 20 SNPs and 4 haplotypes, there were no statistically significant results in the prostate cancer patients andthe controls. In the logistic analysis of SRD5A2 polymorphisms with prostate-specific antigen (PSA) criteria, two SNPs (rs508562,rs11675297) and haplotype 1 displayed significant results (odds ratio [OR], 1.76; p=0.05; OR, 1.88–2.02; p=0.01–0.04; OR, 0.59;p=0.02, respectively). rs508562, rs11675297, rs2208532, and haplotype 1 (OR, 1.49; p=0.05; OR, 2.02; p=0.05; OR, 2.01; p=0.04; OR,0.56–0.64, p=0.03–0.04, respectively) had significant associations with Gleason score. rs508562, rs11675297, and haplotype 1 (OR,1.41–2.34; p=0.004–0.05; OR, 1.74–1.82; p=0.03–0.05; OR, 0.42–0.67; p=0.0005–0.03, respectively) were significantly associatedwith clinical stage.
Conclusions: We conclude that there was no significant association between SRD5A2 SNPs and the risk of prostate cancer in theKorean population. However, we found that some SNPs and 1 haplotype influenced PSA level, Gleason score, and clinical stage.
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참고문헌 (37)
참고문헌 신청
Park SK / 2006 / Rising prostate cancer rates in South Korea / Prostate 66:1285~1291
Chan JM / 2006 / Diet after diagnosis and the risk of prostate cancer progression, recurrence, and death (United States) / Cancer Causes Control 17:199~208
Platz EA / 2004 / The epidemiology of sex steroid hormones and their signaling and metabolic pathways in the etiology of prostate cancer / J Steroid Biochem Mol Biol 92:237~253
Reichardt JK / 1995 / Genetic variability of the human SRD5A2 gene: implications for prostate cancer risk / Cancer Res 55:3973~3975
Bjelfman C / 1997 / Differential gene expression of steroid 5 alphareductase 2 in core needle biopsies from malignant and benign prostatic tissue / J Clin Endocrinol Metab 82:2210~2214
Chan JM / 2006 / Diet after diagnosis and the risk of prostate cancer progression, recurrence, and death (United States) / Cancer Causes Control 17:199~208
Platz EA / 2004 / The epidemiology of sex steroid hormones and their signaling and metabolic pathways in the etiology of prostate cancer / J Steroid Biochem Mol Biol 92:237~253
Reichardt JK / 1995 / Genetic variability of the human SRD5A2 gene: implications for prostate cancer risk / Cancer Res 55:3973~3975
Bjelfman C / 1997 / Differential gene expression of steroid 5 alphareductase 2 in core needle biopsies from malignant and benign prostatic tissue / J Clin Endocrinol Metab 82:2210~2214
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