지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 269 - 275 (7page)
이용수
초록· 키워드
오류제보하기
Background: Snakebite can cause various complications, including coagulopathy. The clinical features of snakebite-associated coagulopathy differ from those of disseminated intravascular coagulation (DIC) caused by other diseases and its treatment is controversial. Methods: We retrospectively reviewed the medical records of patients hospitalized for snakebite between January 2006 and September 2018. Results: A total of 226 patients were hospitalized due to snakebite. Their median hospital stay was 4.0 days (interquartile range, 2.0 to 7.0 days). Five patients arrived at hospital with shock and one patient died. Twenty-one patients had overt DIC according to the International Society of Thrombosis and Hemostasis scoring system. Two patients developed major bleeding complications. Initial lower cholesterol level at presentation was associated with the development of overt DIC. International normalization ratio (INR) exceeding the laboratory’s measurement limit was recorded as late as 4 to 5 days after the bite. Higher antivenom doses (≥18,000 units) and transfusion of fresh frozen plasma (FFP) or cryoprecipitate did not affect prolonged INR duration or hospital stay in the overt DIC patients without bleeding. Conclusions: Initial lower cholesterol level may be a risk factor for overt DIC following snakebite. Although patients lack apparent symptoms, the risk of coagulopathy should be assessed for at least 4 to 5 days following snakebite. Higher antivenom doses and transfusion of FFP or cryoprecipitate may be unbeneficial for coagulopathic patients without bleeding.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
World Health Organization / Venomous snakes distribution and species risk categories [Internet]
Berling I / 2015 / Hematologic effects and complications of snake envenoming / Transfus Med Rev 29:82~89
임훈 / 2013 / 한국 뱀 교상에 대한 항뱀독소 / 대한의사협회지 56(12):1091~1103
Ramos OH / 2006 / Snake venom metalloproteases : structure and function of catalytic and disintegrin domains / Comp Biochem Physiol C Toxicol Pharmacol 142:328~346
Isbister GK / 2009 / Procoagulant snake toxins : laboratory studies, diagnosis, and understanding snakebite coagulopathy / Semin Thromb Hemost 35:93~103
Berling I / 2015 / Hematologic effects and complications of snake envenoming / Transfus Med Rev 29:82~89
임훈 / 2013 / 한국 뱀 교상에 대한 항뱀독소 / 대한의사협회지 56(12):1091~1103
Ramos OH / 2006 / Snake venom metalloproteases : structure and function of catalytic and disintegrin domains / Comp Biochem Physiol C Toxicol Pharmacol 142:328~346
Isbister GK / 2009 / Procoagulant snake toxins : laboratory studies, diagnosis, and understanding snakebite coagulopathy / Semin Thromb Hemost 35:93~103
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