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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 165 - 172 (8page)
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Berberine has been used clinically for more than a decade to treat various diseases, has been shown to be effective in osteoblast differentiation, and is a potential treatment option for osteoporosis. However, compared with existing osteoporosis drugs, berberine is somewhat less effective. This study aimed to identify a new compound with efficacy superior to that of berberine. The osteogenic activities of various berberine derivatives were evaluated via cell differentiation in C2C12 preosteoblast cell lines. Alkaline phosphatase (ALP) staining assay and structure– activity relationship demonstrated that compound 2b had a potent osteogenic effect. Furthermore, compound 2b dose dependently increased ALP activity and showed no toxicity at the effective concentration, indicating its efficacy. Additionally, compound 2b upregulated BMP2-induced transcriptional activity in a promoter activity assay using ALP, BSP, and OC promoters.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Leon Snyman / 2014 / Menopause-related osteoporosis / South African Family Practice 56(3):174~177
Kristine E. Ensrud / 2017 / Osteoporosis / Annals of Internal Medicine 167(3):ITC17~ITC32
Salvatore L. Ruggiero / 2014 / American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw—2014 Update / Journal of Oral and Maxillofacial Surgery 72(10):1938~1956
Marius E. Kraenzlin / 2011 / Parathyroid hormone analogues in the treatment of osteoporosis / Nature Reviews Endocrinology 7(11):647~656
Endo I / 2014 / Bone and Stem Cells. Regulatory mechanism of mesenchymal stem cell differentiation to osteoblasts / Clin Calcium 24:555~564
Kristine E. Ensrud / 2017 / Osteoporosis / Annals of Internal Medicine 167(3):ITC17~ITC32
Salvatore L. Ruggiero / 2014 / American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw—2014 Update / Journal of Oral and Maxillofacial Surgery 72(10):1938~1956
Marius E. Kraenzlin / 2011 / Parathyroid hormone analogues in the treatment of osteoporosis / Nature Reviews Endocrinology 7(11):647~656
Endo I / 2014 / Bone and Stem Cells. Regulatory mechanism of mesenchymal stem cell differentiation to osteoblasts / Clin Calcium 24:555~564
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