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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 160 - 164 (5page)
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초록· 키워드
오류제보하기
Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), Prevotella intermedia (Pi), and Fusobacterium nucleatum (Fn) are major periodontal pathogens. Lipopolysaccharides (LPSs) from periodontal bacteria play an important role in periodontal pathogenesis by stimulating host cells to produce inflammatory cytokines. In this study, highly pure LPSs from the five major periodontopathogens were prepared, and their monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α)-inducing activities were compared in human umbilical vein endothelial cells (HUVECs) and THP-1 macrophagic cells, respectively. In HUVECs, LPSs from Aa and Fn were potent stimulators for MCP-1 induction; however, LPSs from Pg, Pi, and Tf were much weaker MCP-1 inducers. In THP-1 cells, LPSs from Pg, Aa, and Fn were relatively strong inducers of TNF-α, whereas LPSs from Pi and Tf produced little activity. The Toll-like receptor (TLR)2/TLR4 dependency of various LPSs was also determined by measuring NF-κB reporter activity in TLR2- or TLR4-expressing 293 cells. LPSs from Aa, Fn, and Tf stimulated only TLR4; however, LPSs from Pg and Pi stimulated both TLR2 and TLR4. These results suggest that LPSs from major periodontal bacteria differ considerably in their cell-stimulating activity.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Eija Könönen / 2019 / Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues / Journal of Clinical Medicine 8(8):E1135
Gunnar Dahlen / 2019 / Importance of Virulence Factors for the Persistence of Oral Bacteria in the Inflamed Gingival Crevice and in the Pathogenesis of Periodontal Disease / Journal of Clinical Medicine 8(9):E1339
Weiyi Pan / 2019 / The cytokine network involved in the host immune response to periodontitis / International Journal of Oral Science 11(3):30
D. T. Graves / 1999 / The Potential Role of Chemokines and Inflammatory Cytokines in Periodontal Disease Progression / Clinical Infectious Diseases 28(3):482~490
이상훈 / 2014 / Lipopolysaccharide: Basic Biochemistry, Intracellular Signaling, and Physiological Impacts in the Gut / Intestinal research 12(2):90~95
Gunnar Dahlen / 2019 / Importance of Virulence Factors for the Persistence of Oral Bacteria in the Inflamed Gingival Crevice and in the Pathogenesis of Periodontal Disease / Journal of Clinical Medicine 8(9):E1339
Weiyi Pan / 2019 / The cytokine network involved in the host immune response to periodontitis / International Journal of Oral Science 11(3):30
D. T. Graves / 1999 / The Potential Role of Chemokines and Inflammatory Cytokines in Periodontal Disease Progression / Clinical Infectious Diseases 28(3):482~490
이상훈 / 2014 / Lipopolysaccharide: Basic Biochemistry, Intracellular Signaling, and Physiological Impacts in the Gut / Intestinal research 12(2):90~95
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