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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제1호
- 발행연도
- 2020.1
- 수록면
- 1 - 10 (10page)
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FK506, also known as tacrolimus, is a clinically important immunosuppressant drug and has promising therapeutic potentials owing to its antifungal, neuroprotective, and neuroregenerative activities. To generate various FK506 derivatives, the structure of FK506 has been modified by chemical methods or biosynthetic pathway engineering. Herein, we describe the mode of the antifungal action of FK506 and the structure–activity relationship of FK506 derivatives in the context of immunosuppressive and antifungal activities. In addition, we discuss the neurotrophic mechanism of FK506 known to date, along with the neurotrophic FK506 derivatives with significantly reduced immunosuppressive activity. This review suggests the possibility to generate novel FK506 derivatives as antifungal as well as neuroregenerative/neuroprotective agents.
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참고문헌 (80)
참고문헌 신청
Kino T / 1987 / FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro / J. Antibiot. 40:1256~1265
Parsons WH / 1993 / FK-506--a novel immunosuppressant / Ann. NY Acad. Sci 685:22~36
Kino T / 1987 / FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics / J. Antibiot. 40:1249~1255
Ban YH / 2016 / The biosynthetic pathway of FK506 and its engineering : from past achievements to future prospects / J. Ind. Microbiol. Biotechnol 43:389~400
Barreiro C / 2014 / Trends in the biosynthesis and production of the immunosuppressant tacrolimus(FK506) / Appl. Microbiol. Biotechnol 98:497~507
Parsons WH / 1993 / FK-506--a novel immunosuppressant / Ann. NY Acad. Sci 685:22~36
Kino T / 1987 / FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics / J. Antibiot. 40:1249~1255
Ban YH / 2016 / The biosynthetic pathway of FK506 and its engineering : from past achievements to future prospects / J. Ind. Microbiol. Biotechnol 43:389~400
Barreiro C / 2014 / Trends in the biosynthesis and production of the immunosuppressant tacrolimus(FK506) / Appl. Microbiol. Biotechnol 98:497~507
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