지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Candidiasis control should include monitoring the epidemiology and resistance to various antifungal agents. In this study, the researchers investigated the Candida species recovered from clinical specimens at particular geographic areas or hospitals. Objective: The present study is geared toward the evaluation of antifungal drug usage at Korean hospitals in 2016. It is also essential that species distribution and antifungal susceptibilities of Candida isolates should be looked into to provide important data that can help devise therapeutic strategies to control the disease. Methods: Systemic antifungal agent usage over a one-year period was investigated at 10 Korean hospitals. Identification and antifungal susceptibility tests were performed on clinical isolates of the Candida species, which were collected over a three-month period. Results: The total antifungal usage in each hospital ranged from 7.7 to 158.9 defined daily doses (DDDs) per 1,000 patient days. Fluconazole was most commonly used (37.1%), followed by amphotericin B (30.6%), itraconazole (9.7%), echinocandins (8.8%), voriconazole (7.5%), and posaconazole (6.3%), respectively. Among 274 Candida isolates, C. albicans was the most frequently recovered (51.1%), followed by C. glabrata (15.7%), C. tropicalis (15.0%), and C. parapsilosis (13.5%), respectively. Through the application of either species-specific clinical breakpoints or epidemiological cutoff values to Candida isolates, the non-susceptibility rates to fluconazole, voriconazole, amphotericin B, and micafungin were found in 20.7%, 5.6%, 0%, and 0% of isolates, respectively. Conclusion: This nationwide multicenter study showed that total antifungal use varied considerably according to each hospital. Non-susceptibility to fluconazole should be further monitored, considering the drug's frequent use in Korea.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Pfaller MA / 2007 / Epidemiology of invasive candidiasis : a persistent public health problem / Clin Microbiol Rev 20:133~163
Pappas PG / 2016 / Clinical practice guideline for the management of candidiasis : 2016 update by the Infectious Diseases Society of America / Clin Infect Dis 62:e1~50
Kim SH / 2009 / The relationship between antifungal usage and antifungal susceptibility in clinical isolates of Candida : a multicenter Korean study / Med Mycol 47:296~304
Fournier P / 2011 / Antifungal use influences Candida species distribution and susceptibility in the intensive care unit / J Antimicrob Chemother 66:2880~2886
Won EJ / 2015 / Antifungal susceptibilities of bloodstream isolates of Candida species from nine hospitals in Korea : application of new antifungal breakpoints and relationship to antifungal usage / PLoS One 10:e0118770
Pappas PG / 2016 / Clinical practice guideline for the management of candidiasis : 2016 update by the Infectious Diseases Society of America / Clin Infect Dis 62:e1~50
Kim SH / 2009 / The relationship between antifungal usage and antifungal susceptibility in clinical isolates of Candida : a multicenter Korean study / Med Mycol 47:296~304
Fournier P / 2011 / Antifungal use influences Candida species distribution and susceptibility in the intensive care unit / J Antimicrob Chemother 66:2880~2886
Won EJ / 2015 / Antifungal susceptibilities of bloodstream isolates of Candida species from nine hospitals in Korea : application of new antifungal breakpoints and relationship to antifungal usage / PLoS One 10:e0118770
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Novel Approaches for Efficient Antifungal Drug Action
Journal of Microbiology and Biotechnology
2018 .01
-
The Putative Fungicidal Molecules Show an Antifungal Effect on Candida albicans Virulence Through a Regulating the Mitochondrial Activity
한국미생물학회 학술대회논문집
2016 .04
-
기관지 생검이 진단에 도움이 된 Candida albicans 폐렴 1예
대한의진균학회지
2015 .01
-
Identification of Bacteria Isolated from Barley Rhizosphere Soil and Their Antifungal Activity
한국미생물학회 학술대회논문집
2022 .10
-
Identification of Candida Species Using 26S Ribosomal RNA Gene Sequencing in Patients with Periodontitis
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .12
-
Large-Scale Screening of the Plant Extracts for Antifungal Activity against the Plant Pathogenic Fungi
The Plant Pathology Journal
2022 .12
-
In Vitro Antifungal Activity of (1)-N-2-Methoxybenzyl-1,10-phenanthrolinium Bromide against Candida albicans and Its Effects on Membrane Integrity
Mycobiology
2017 .01
-
Effects of Temperature and Culture Media Composition on Sporulation, Mycelial Growth, and Antifungal Activity of Isaria javanica pf185
Research in Plant Disease(식물병연구)
2021 .09
-
손발톱진균증의 전신 항진균제
대한의진균학회지
2016 .01
-
Adenylyl Cyclase and Protein Kinase A Play Critical and Individual Roles in Antifungal Drug Resistance and Pathogenicity of Candida auris
한국미생물학회 학술대회논문집
2021 .08
-
Antifungal Activity of Salvia miltiorrhiza Against Candida albicans Is Associated with the Alteration of Membrane Permeability and (1,3)-β-D-Glucan Synthase Activity
Journal of Microbiology and Biotechnology
2016 .01
-
Optimization of Medium Composition and Culture Conditions for the Antifungal Activity of Bacillus Strain 4-3
한국미생물학회 학술대회논문집
2015 .04
-
Identification and Characterization of the Antifungal Substances of a Novel Streptomyces cavourensis NA4
Journal of Microbiology and Biotechnology
2015 .01
-
Antifungal Activities of Streptomyces blastmyceticus Strain 12-6 Against Plant Pathogenic Fungi
Mycobiology
2019 .01
-
Genetic Variations of Candida glabrata Clinical Isolates from Korea using Multi-locus Sequence Typing
생명과학회지
2020 .02
-
미나리아재비과 한약재의 항진균성 검증 및 비교 연구
생명과학회지
2024 .06
-
Identification of Uncommon Candida Species Using Commercial Identification Systems
Journal of Microbiology and Biotechnology
2016 .12
-
Late Onset Candida albicans Spondylodiscitis Following Candidemia: A Case Report
대한의진균학회지
2017 .01
-
In vitro and in vivo Characterization of Antifungal Drug Efficacy of FK506 Analogs
한국미생물학회 학술대회논문집
2017 .04
-
여러 독소생성 진균에 대한 토양에서 분리된 세균들의 항진균 활성
미생물학회지
2019 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0