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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 173 - 180 (8page)
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초록· 키워드
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Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic biomarker of various diseases, including heart disease, kidney disease, and cancer. Galectin-3 exists as a cytosol, is secreted in extracellular spaces on cells, and is also detected in nuclei. It has been found that galectin-3 has different functions in cellular localization: (i) Extracellular galectin-3 mediates cell attachment and detachment. (ii) cytosolic galectin-3 regulates cell survival by blocking the intrinsic apoptotic pathway, and (iii) nuclear galectin-3 supports the ability of the transcriptional factor for target gene expression. In this review, we focused on the role of galectin-3 on translocation from cytosol to nucleus, because it happens in a way independent of carbohydrate recognition and accelerates cancer progression. We also suggested here that intracellular galecin-3 could be a potent therapeutic target in cancer therapy.
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참고문헌 (109)
참고문헌 신청
Dumic J / 2006 / Galectin-3 : an open-ended story / Biochim Biophys Acta 1760:616~635
Leffler H / 2002 / Introduction to galectins / Glycoconj J 19:433~440
Drickamer K / 2002 / Genomic analysis of C-type lectins / Biochem Soc Symp 69:59~72
Liu FT / 2005 / Galectins as modulators of tumour progression / Nat Rev Cancer 5:29~41
Fortuna-Costa A / 2014 / Extracellular galectin-3 in tumor progression and metastasis / Front Oncol 4:138
Leffler H / 2002 / Introduction to galectins / Glycoconj J 19:433~440
Drickamer K / 2002 / Genomic analysis of C-type lectins / Biochem Soc Symp 69:59~72
Liu FT / 2005 / Galectins as modulators of tumour progression / Nat Rev Cancer 5:29~41
Fortuna-Costa A / 2014 / Extracellular galectin-3 in tumor progression and metastasis / Front Oncol 4:138
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