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- 2017.1
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The endoplasmic reticulum (ER) is an important subcellular organelle that is involved in numerous activities required to achieve and maintain functional proteins in addition to its role in the biosynthesis of lipids and as a repository of intracellular Ca2+.
The inability of the ER to cope with protein folding beyond its capacity causes disturbances that evoke ER stress. Cells possess molecular mechanisms aimed at clearing unwanted cargo from the ER lumen as an adaptive response, but failing to do so navigates the system towards cell death. This systemic approach is called the unfolded protein response. Aging insults cells through various perturbations in homeostasis that involve curtailing ER function by mitigating the expression of its resident chaperones and enzymes. Here the unfolded protein response (UPR) cannot protect the cell due to the weakening of its protective arm, which exacerbates imbalanced homeostasis. Aging predisposed breast malignancy activates the UPR, but tumor cells maneuver the mechanistic details of the UPR, favoring tumorigenesis and thereby eliciting a treacherous condition. Tumor cells exploit UPR pathways via crosstalk involving various signaling cascades that usher tumor cells to immortality. This review aims to present a collection of data that can delineate the missing links of molecular signatures between aging and breast cancer.
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참고문헌 (25)
참고문헌 신청
American Cancer Society / 2015 / Breast Cancer Facts & Figures 2015-2016 / American Cancer Society
Bastien RRL / 2012 / PAM50 breast cancer subtyping by RT-qPCR and concordance with standard clinical molecular markers / BMC Med Genomics 5 : 44 ~ 44
Dever TE / 2002 / Gene-specific regulation by general translation factors / Cell 108 : 545 ~ 556
Ellgaard L / 2003 / Quality control in the endoplasmic reticulum / Nat Rev Mol Cell Biol 4 : 181 ~ 191
Erickson RR / 2006 / The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to t
Bastien RRL / 2012 / PAM50 breast cancer subtyping by RT-qPCR and concordance with standard clinical molecular markers / BMC Med Genomics 5 : 44 ~ 44
Dever TE / 2002 / Gene-specific regulation by general translation factors / Cell 108 : 545 ~ 556
Ellgaard L / 2003 / Quality control in the endoplasmic reticulum / Nat Rev Mol Cell Biol 4 : 181 ~ 191
Erickson RR / 2006 / The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to t
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