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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 118 - 123 (6page)
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Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchymal stromal cells (h-CMSCs) by means of three-dimensional organ culture (3D culture) during ex vivo expansion of cardiac tissue, to compare the functional efficacy with human bone-marrow derived mesenchymal stem cells (h-BM-MSCs), one of the actively studied ASCs. We characterized the h-CMSCs as CD90low, c-kitnegative, CD105positive phenotype and these cells express NANOG, SOX2, and GATA4. To identify the more effective type of EVs for angiogenesis among the different sources of ASCs, we isolated EVs which were derived from CMSCs with either normoxic or hypoxic condition and BM-MSCs. Our in vitro tube-formation results demonstrated that the angiogenic effects of EVs from hypoxia-treated CMSCs (CMSC-Hpx EVs) were greater than the well-known effects of EVs from BM-MSCs (BM-MSC EVs), and these were even comparable to human vascular endothelial growth factor (hVEGF), a potent angiogenic factor. Therefore, we present here that CD90lowc-kitnegativeCD105positive CMSCs under hypoxic conditions secrete functionally superior EVs for in vitro angiogenesis. Our findings will allow more insights on understanding myocardial repair.
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참고문헌 (39)
참고문헌 신청
Benjamin EJ / 2019 / Heart Disease and Stroke Statistics-2019 Update : A Report From the American Heart Association / Circulation 139:e56~e528
Cambria E / 2017 / Translational cardiac stem cell therapy : advancing from first-generation to next-generation cell types / NPJ Regen Med 2:17
Makkar RR / 2012 / Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction(CADUCEUS) : a prospective, randomised phase 1 trial / Lancet 379:895~904
Parizadeh SM / 2019 / Stem cell therapy : A novel approach for myocardial infarction / J Cell Physiol 234:16904~16912
Yun CW / 2019 / Enhancement of Functionality and Therapeutic Efficacy of Cell-Based Therapy Using Mesenchymal Stem Cells for Cardiovascular Disease / Int J Mol Sci 20:982
Cambria E / 2017 / Translational cardiac stem cell therapy : advancing from first-generation to next-generation cell types / NPJ Regen Med 2:17
Makkar RR / 2012 / Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction(CADUCEUS) : a prospective, randomised phase 1 trial / Lancet 379:895~904
Parizadeh SM / 2019 / Stem cell therapy : A novel approach for myocardial infarction / J Cell Physiol 234:16904~16912
Yun CW / 2019 / Enhancement of Functionality and Therapeutic Efficacy of Cell-Based Therapy Using Mesenchymal Stem Cells for Cardiovascular Disease / Int J Mol Sci 20:982
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