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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 641 - 646 (6page)
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The Ron proto-oncogene is a human receptor for macrophage-stimulating protein (MSP). The exclusion of exon 11 in alternative splicing generates RON protein that is constitutively activated. Heterogenous ribonucleaoprotein (hnRNP) C1/C2 is one of the most abundant proteins in cells. In this manuscript, we showed that both hnRNP C1 and C2 promoted exon 11 inclusion of Ron pre-mRNA and that hnRNP C1 and hnRNP C2 functioned independently but not cooperatively. Moreover, hnRNP C1 stimulated exon 11 splicing through intron 10 activation but not through intron 11 splicing. Furthermore, we showed that, whereas the RRM domain was required for hnRNP C1 function, the Asp/Glu domain was not. In conclusion, hnRNP C1/C2 promoted exon 11 splicing independently by stimulating intron 10 splicing through RRM but not through the Asp/Glu domain.
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참고문헌 (23)
참고문헌 신청
Wahl MC / 2009 / The spliceosome : design principles of a dynamic RNP machine / Cell 136:701~718
Papoff G / 1996 / An N-terminal domain shared by Fas/Apo-1(CD95)soluble variants prevents cell death in vitro / J Immunol 156:4622~4630
Droin N / 2001 / Modulation of apoptosis by procaspase-2short isoform : selective inhibition of chromatin condensation, apoptotic body formation and phosphatidylserine externalization / Oncogene 20:260~269
Kroemer G / 1997 / The proto-oncogene Bcl-2 and its role in regulating apoptosis / Nat Med 3:614~620
Iwama A / 1994 / Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells / Blood 83:3160~3169
Papoff G / 1996 / An N-terminal domain shared by Fas/Apo-1(CD95)soluble variants prevents cell death in vitro / J Immunol 156:4622~4630
Droin N / 2001 / Modulation of apoptosis by procaspase-2short isoform : selective inhibition of chromatin condensation, apoptotic body formation and phosphatidylserine externalization / Oncogene 20:260~269
Kroemer G / 1997 / The proto-oncogene Bcl-2 and its role in regulating apoptosis / Nat Med 3:614~620
Iwama A / 1994 / Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells / Blood 83:3160~3169
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