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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 405 - 413 (9page)
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Tau proteins, which stabilize the structure and regulate the dynamics of microtubules, also play important roles in axonal transport and signal transduction. Tau proteins are missorted, aggregated, and found as tau inclusions under many pathological conditions associated with neurodegenerative disorders, which are collectively known as tauopathies. In the adult human brain, tau protein can be expressed in six isoforms due to alternative splicing. The aberrant splicing of tau pre-mRNA has been consistently identified in a variety of tauopathies but is not restricted to these types of disorders as it is also present in patients with non-tau proteinopathies and RNAopathies. Tau mis-splicing results in isoform-specific impairments in normal physiological function and enhanced recruitment of excessive tau isoforms into the pathological process. A variety of factors are involved in the complex set of mechanisms underlying tau mis-splicing, but variation in the cis-element, methylation of the MAPT gene, genetic polymorphisms, the quantity and activity of spliceosomal proteins, and the patency of other RNA-binding proteins, are related to aberrant splicing. Currently, there is a lack of appropriate therapeutic strategies aimed at correcting the tau mis-splicing process in patients with neurodegenerative disorders. Thus, a more comprehensive understanding of the relationship between tau mis-splicing and neurodegenerative disorders will aid in the development of efficient therapeutic strategies for patients with a tauopathy or other, related neurodegenerative disorders.
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참고문헌 (99)
참고문헌 신청
Dixit R / 2008 / Differential regulation of dynein and kinesin motor proteins by tau / Science 319:1086~1089
Munoz DG / 2008 / Neuropathology of hereditary forms of frontotemporal dementia and parkinsonism / Handb Clin Neurol 89:393~414
Togo T / 2002 / Argyrophilic grain disease is a sporadic 4-repeat tauopathy / J Neuropathol Exp Neurol 61:547~556
Arai T / 2001 / Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy / Acta Neuropathol 101:167~173
Sergeant N / 2001 / Dysregulation of human brain microtubuleassociated tau mRNA maturation in myotonic dystrophy type 1 / Hum Mol Genet 10:2143~2155
Munoz DG / 2008 / Neuropathology of hereditary forms of frontotemporal dementia and parkinsonism / Handb Clin Neurol 89:393~414
Togo T / 2002 / Argyrophilic grain disease is a sporadic 4-repeat tauopathy / J Neuropathol Exp Neurol 61:547~556
Arai T / 2001 / Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy / Acta Neuropathol 101:167~173
Sergeant N / 2001 / Dysregulation of human brain microtubuleassociated tau mRNA maturation in myotonic dystrophy type 1 / Hum Mol Genet 10:2143~2155
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