지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 647 - 652 (6page)
이용수
초록· 키워드
오류제보하기
G protein-coupled estrogen receptor (GPER) is known to play an important role in hormone-associated cancers. G-1, a novel synthetic GPER agonist, has been reported to exhibit anti-carcinogenic properties. However, the chemotherapeutic mechanism of GPER is yet unclear. Here, we evaluated GPER expression in human gastric cancer tissues and cells. We found that G-1 treatment attenuates GPER expression in gastric cancer. GPER expression increased G-1-induced antitumor effects in mouse xenograft model. We analyzed the effects of knockdown/overexpression of GPER on G-1-induced cell death in cancer cells. Increased GPER expression in human gastric cancer cells increased G-1-induced cell death via increased levels of cleaved caspase-3, -9, and cleaved poly ADP-ribose polymerase. Interestingly, during G-1-induced cell death, GPER mRNA and protein expression was attenuated and associated with ER stress-induced expression of PERK, ATF-4, GRP-78, and CHOP. Furthermore, PERK-dependent induction of ER stress activation increased G-1-induced cell death, whereas PERK silencing decreased cell death and increased drug sensitivity. Taken together, the data suggest that the induction of ER stress via GPER expression may increase G-1-induced cell death in gastric cancer cells. These results may contribute to a new paradigm shift in gastric cancer therapy.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
박강서 / 2018 / HSP90 inhibitor, AUY922, debilitates intrinsic and acquired lapatinib-resistant HER2-positive gastric cancer cells / BMB Reports 51(12):660~665
서재성 / 2018 / Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis / BMB Reports 51(5):255~260
Simon MS / 2012 / Estrogen plus progestin and colorectal cancer incidence and mortality / J Am Soc Clin Oncol 30:3983~3990
Ariazi EA / 2010 / The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells / Cancer Res 70:1184~1194
Wang C / 2013 / The G protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization / Cell Death Dis 4:e869
서재성 / 2018 / Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis / BMB Reports 51(5):255~260
Simon MS / 2012 / Estrogen plus progestin and colorectal cancer incidence and mortality / J Am Soc Clin Oncol 30:3983~3990
Ariazi EA / 2010 / The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells / Cancer Res 70:1184~1194
Wang C / 2013 / The G protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization / Cell Death Dis 4:e869
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages
Experimental and Molecular Medicine
2023 .02
-
ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer
BMB Reports
2017 .01
-
ER Stress-driven BCL-2 Overexpression Inhibits Cell Death in CHO Cells
한국생물공학회 학술대회
2020 .10
-
The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer
Experimental and Molecular Medicine
2024 .01
-
Identification of gastric cancer biomarkers by comparison of the breath profiles of gastric cancer patients and healthy subjects
한국생물공학회 학술대회
2016 .10
-
Survivin protects fused cancer cells from cell death
BMB Reports
2017 .07
-
Entosis: the core mechanism and crosstalk with other cell death programs
Experimental and Molecular Medicine
2024 .04
-
Nucleotide-binding oligomerization domain protein 2 attenuates ER stress-induced cell death in vascular smooth muscle cells
BMB Reports
2019 .01
-
CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1α-JNK pathways
Experimental and Molecular Medicine
2024 .01
-
A novel targeting material to receptors of cancer cells
한국생물공학회 학술대회
2018 .04
-
딥러닝 기반 위 질환 컴퓨터 보조 진단 시스템 개발 및 Grad-CAM을 활용한 시각화
전기학회논문지
2023 .02
-
Targeting and Anti-cancer Activity of Conjugated Exosome in Breast Cancer
한국생물공학회 학술대회
2021 .04
-
Cholecystokinin as a Potent Diagnostic Marker for Gastric Cancer
BioChip Journal
2017 .01
-
Co-Culturing Cancer Cells and Normal Cells in a Biochip under Electrical Stimulation
BioChip Journal
2018 .01
-
Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells
Experimental and Molecular Medicine
2021 .09
-
Deep Learning-Based Automated Analysis of NK Cell Cytotoxicity in Single Cancer Cell Arrays
BioChip Journal
2024 .09
-
Cell Targeting Efficiency Comparison of Tumor Cell Receptor Binding and Cell Penetrating Peptide on the surface of human ferritin heavy chain
한국생물공학회 학술대회
2019 .04
-
The Use of Normal Stem Cells and Cancer Stem Cells for Potential Anti-Cancer Therapeutic Strategy
조직공학과 재생의학
2018 .01
-
Fumonisin B₁ Exerts Its Toxic Effect on Spleen Tissue by Oxidative Stress Induced ER Stress Pathway
한국생물공학회 학술대회
2015 .04
-
Cancer Cell Growth in the Near Infrared Region by Using Silica Coated Gold Nanorods
NANO
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0