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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 595 - 600 (6page)
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초록· 키워드
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Cardiac fibrosis is a common feature in chronic hypertension patients with advanced heart failure, and endothelial-tomesenchymal transition (EndMT) is known to promote Angiotensin II (Ang II)-mediated cardiac fibrosis. Previous studies have suggested a potential role for the transcription factor, ETS-1, in Ang II-mediated cardiac remodeling, however the mechanism are not well defined. In this study, we found that mice with endothelial Ets-1 deletion showed reduced cardiac fibrosis and hypertrophy following Ang II infusion. The reduced cardiac fibrosis was accompanied by decreased expression of fibrotic matrix genes, reduced EndMT with decreased Snail, Slug, Twist, and ZEB1 expression, as well as reduced cardiac hypertrophy and expression of hypertrophyassociated genes was observed. In vitro studies using cultured H5V cells further confirmed that ETS-1 knockdown inhibited TGF-1-induced EndMT. This study revealed that deletion of endothelial Ets-1 attenuated Ang II-induced cardiac fibrosis via inhibition of EndMT, indicating an important ETS-1 function in mediating EndMT. Inhibition of ETS-1 could be a potential therapeutic strategy for treatment of heart failure secondary to chronic hypertension.
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참고문헌 (24)
참고문헌 신청
Gourdie RG / 2016 / Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease / Nat Rev Drug Discov 15:620~638
Furtado MB / 2016 / View from the heart : cardiac fibroblasts in development, scarring and regeneration / Development 143:387~397
Ho CY / 2010 / Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy / N Engl J Med 363:552~563
Piera-Velazquez S / 2011 / Role of endothelial-mesenchymal transition(EndoMT)in the pathogenesis of fibrotic disorders / Am J Pathol 179:1074~1080
Zeisberg EM / 2008 / Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition / J Am Soc Nephrol 19:2282~2287
Furtado MB / 2016 / View from the heart : cardiac fibroblasts in development, scarring and regeneration / Development 143:387~397
Ho CY / 2010 / Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy / N Engl J Med 363:552~563
Piera-Velazquez S / 2011 / Role of endothelial-mesenchymal transition(EndoMT)in the pathogenesis of fibrotic disorders / Am J Pathol 179:1074~1080
Zeisberg EM / 2008 / Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition / J Am Soc Nephrol 19:2282~2287
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