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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 607 - 612 (6page)
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초록· 키워드
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During meiosis, programmed double-strand breaks (DSBs) are repaired via recombination pathways that are required for faithful chromosomal segregation and genetic diversity. In meiotic progression, the non-homologous end joining (NHEJ) pathway is suppressed and instead meiotic recombination initiated by nucleolytic resection of DSB ends is the major pathway employed. This requires diverse recombinase proteins and regulatory factors involved in the formation of crossovers (COs) and non-crossovers (NCOs). In mitosis, spontaneous DSBs occurring at the G1 phase are predominantly repaired via NHEJ, mediating the joining of DNA ends. The Ku complex binds to these DSB ends, inhibiting additional DSB resection and mediating end joining with Dnl4, Lif1, and Nej1, which join the Ku complex and DSB ends. Here, we report the role of the Ku complex in DSB repair using a physical analysis of recombination in Saccharomyces cerevisiae during meiosis. We found that the Ku complex is not essential for meiotic progression, DSB formation, joint molecule formation, or CO/NCO formation during normal meiosis. Surprisingly, in the absence of the Ku complex and functional Mre11-Rad50-Xrs2 (MRX) complex, a large portion of meiotic DSBs was repaired via the recombination pathway to form COs and NCOs. Our data suggested that Ku complex prevents meiotic recombination in the elimination of MRX activity.
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참고문헌 (35)
참고문헌 신청
정우현 / 2014 / To Peep into Pif1 Helicase: Multifaceted All the Way from Genome Stability to Repair-Associated DNA Synthesis / The Journal of Microbiology 52(2):89~98
최도희 / 2013 / Hrq1 Functions Independently of Sgs1 to Preserve Genome Integrity in Saccharomyces cerevisiae / The Journal of Microbiology 51(1):105~112
Sung P / 2018 / Introduction to the Thematic Minireview Series : DNA double-strand break repair and pathway choice / J Biol Chem 293:10500~10501
Haber JE / 2018 / DNA Repair : The Search for Homology / BioEssays 40:1700229
Fouquin A / 2017 / PARP2controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection / Nucleic Acids Res 45:12325~12339
최도희 / 2013 / Hrq1 Functions Independently of Sgs1 to Preserve Genome Integrity in Saccharomyces cerevisiae / The Journal of Microbiology 51(1):105~112
Sung P / 2018 / Introduction to the Thematic Minireview Series : DNA double-strand break repair and pathway choice / J Biol Chem 293:10500~10501
Haber JE / 2018 / DNA Repair : The Search for Homology / BioEssays 40:1700229
Fouquin A / 2017 / PARP2controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection / Nucleic Acids Res 45:12325~12339
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