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논문 기본 정보

자료유형
학술저널
저자정보
Sun Woo Lim (The Catholic University of Korea) Kang Luo (The Catholic University of Korea) Yi Quan (The Catholic University of Korea) Sheng Cui (The Catholic University of Korea) Yoo Jin Shin (The Catholic University of Korea) Eun Jeong Ko (The Catholic University of Korea) Byung Ha Chung (The Catholic University of Korea) Chul Woo Yang (The Catholic University of Korea)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.44 No.3
발행연도
2020.5
수록면
399 - 404 (6page)

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초록· 키워드

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Korean ginseng (Panax ginseng) is associated with a variety of therapeutic effects, including antioxidative, anti-inflammatory, vasorelaxative, antiallergic, antidiabetic, and anticancer effects. Accordingly, the use of ginseng has reached an all-time high among members of the general public. However, the safety and efficacy of ginseng in transplant recipients receiving immunosuppressant drugs have still not been elucidated. Transplantation is the most challenging and complex of surgical procedures and may require causation for the use of ginseng. In this regard, we have previously examined the safety, immunological benefits, and protective mechanisms of ginseng with respect to calcineurin inhibitor-based immunosuppression, which is the most widely used regimen in organ transplantation. Using an experimental model of calcineurin inhibitor-induced organ injury, we found that ginseng does not affect drug levels in the peripheral blood and tissue, favorably regulates immune response, and protects against calcineurin inhibitor-induced nephrotoxicity and pancreatic islet injury. On the basis of our experimental studies and a review of the related literature, we propose that ginseng may provide benefits in organ transplant recipients administered calcineurin inhibitors. Through the present review, we aimed to briefly discuss our current understanding of the therapeutic benefits of ginseng related to transplant patient survival.

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ABSTRACT
1. Introduction
2. Safety aspects
3. Immunological benefits
4. The protective mechanism of ginseng
5. Conclusion
References

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