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논문 기본 정보

자료유형
학술저널
저자정보
김명주 (이화여자대학교) 송유미 (이화여자대학교) 서채원 (이화여자대학교) 마지영 (유타대학교) 홍가혜 (이화여자대학교) 김정윤 (이화여자대학교)
저널정보
대한생물치료정신의학회 생물치료정신의학 생물치료정신의학 제26권 제2호(통권 제58호)
발행연도
2020.6
수록면
101 - 115 (15page)

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Repetitive transcranial magnetic stimulation (rTMS) is widely recognized as an effective and noninvasive neuromodulation for treating depression, and has been applied in a wide range of clinical settings. However, previous studies often reported inconsistent antidepressant effects that may be due to differences in the rTMS protocols such as coil placement. The typical simulation site for rTMS depression protocol is the left dorsolateral prefrontal cortex (DLPFC). Targeting the exact site of the left DLPFC while considering individual brain structure has been challenging due to the non-invasive nature of rTMS. Several researchers have applied various targeting methods to overcome the abovementioned issue. Most of the previous studies have applied the “5-cm rule” or the “international 10-20 system,” which is easily applicable. Recently, researchers started to apply a neuronavigation system that targets the stimulation site based on neuroimaging of each individual. Pros and cons of targeting methods have been discussed in terms of validity and reliability of targeting stimulation sites, differences in treatment responses, as well as considerations of individual characteristics. Therefore, the current review focuses on the targeting methods of stimulation site and the treatment effects of depression in previous studies. For discussion, we divided neuronavigation methods into using fixed coordinates and using individualized targets. Furthermore, the limitations of each targeting method are discussed that may potentially contribute to the development of the optimal rTMS protocol for depression treatment.

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UCI(KEPA) : I410-ECN-0101-2020-512-000659399