지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 517 - 526 (10page)
이용수
초록· 키워드
오류제보하기
Background: The root of Panax ginseng, a member of Araliaceae family, has been used as herbal medicine and functional food in Asia for thousands of years. According to Traditional Chinese medicine, ginseng is the most widely used “Qi-invigorating” herbs, which provides tonic and preventive effects by resisting oxidative stress, influencing energy metabolism, and improving mitochondrial function. Very few reports have systematically measured cell mitochondrial bioenergetics after ginseng treatment.
Methods: Here, H9C2 cell line, a rat cardiomyoblast, was treated with ginseng extracts having extracted using solvents of different polarity, i.e., water, 50% ethanol, and 90% ethanol, and subsequently, the oxygen consumption rate in healthy and tert-butyl hydroperoxide-treated live cultures was determined by Seahorse extracellular flux analyzer.
Results: The 90% ethanol extracts of ginseng possessed the strongest antioxidative and tonic activities to mitochondrial respiration and therefore provided the best protective effects to H9C2 cardiomyocytes. By increasing the spare respiratory capacity of stressed H9C2 cells up to three-folds of that of healthy cells, the 90% ethanol extracts of ginseng greatly improved the tolerance of myocardial cells to oxidative damage.
Conclusion: These results demonstrated that the low polarity extracts of ginseng could be the best extract, as compared with others, in regulating the oxygen consumption rate of cultured cardiomyocytes during mitochondrial respiration.
Methods: Here, H9C2 cell line, a rat cardiomyoblast, was treated with ginseng extracts having extracted using solvents of different polarity, i.e., water, 50% ethanol, and 90% ethanol, and subsequently, the oxygen consumption rate in healthy and tert-butyl hydroperoxide-treated live cultures was determined by Seahorse extracellular flux analyzer.
Results: The 90% ethanol extracts of ginseng possessed the strongest antioxidative and tonic activities to mitochondrial respiration and therefore provided the best protective effects to H9C2 cardiomyocytes. By increasing the spare respiratory capacity of stressed H9C2 cells up to three-folds of that of healthy cells, the 90% ethanol extracts of ginseng greatly improved the tolerance of myocardial cells to oxidative damage.
Conclusion: These results demonstrated that the low polarity extracts of ginseng could be the best extract, as compared with others, in regulating the oxygen consumption rate of cultured cardiomyocytes during mitochondrial respiration.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (46)
참고문헌 신청
Cheng Y / 2005 / Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action / Acta Pharmacol Sin 26:143~149
Park JS / 2009 / Anti-inflammatory mechanism of ginseng saponins in activated microglia / J Neuroimmunol 209:40~49
Keum YS / 2000 / Antioxidant and anti-tumor promoting activities of the methanol extract of heatprocessed ginseng / Cancer Lett 150:41~48
김종훈 / 2012 / Cardiovascular Diseases and Panax ginseng: A Review on Molecular Mechanisms and Medical Applications / Journal of Ginseng Research 36(1):16~26
백은복 / 2009 / Inhibition of Arterial Myogenic Responses by a Mixed Aqueous Extract of Salvia Miltiorrhiza and Panax Notoginseng (PASEL) Showing Antihypertensive Effects / The Korean Journal of Physiology & Pharmacology 13(4):287~293
Park JS / 2009 / Anti-inflammatory mechanism of ginseng saponins in activated microglia / J Neuroimmunol 209:40~49
Keum YS / 2000 / Antioxidant and anti-tumor promoting activities of the methanol extract of heatprocessed ginseng / Cancer Lett 150:41~48
김종훈 / 2012 / Cardiovascular Diseases and Panax ginseng: A Review on Molecular Mechanisms and Medical Applications / Journal of Ginseng Research 36(1):16~26
백은복 / 2009 / Inhibition of Arterial Myogenic Responses by a Mixed Aqueous Extract of Salvia Miltiorrhiza and Panax Notoginseng (PASEL) Showing Antihypertensive Effects / The Korean Journal of Physiology & Pharmacology 13(4):287~293
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