지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 471 - 482 (12page)
- DOI
- 10.5143/JESK.2019.38.6.471
이용수
초록· 키워드
오류제보하기
Objective: The aim of this study is to identify the altered functional connectivities of the salience network during resting state among individual with alcohol use disorder using functional magnetic resonance imaging.
Background: Individuals with Alcohol Use Disorder (AUD) has shown significant attention and attraction to alcohol-related stimuli. The previous studies demonstrated the neuropsychological, physiological responses elicited by alcohol-related cue. These researches suggested the altered functional connectivities between brain areas related to incentive salience among AUD patients, but not yet fully explored the functional connectivities in salience network during resting-state among AUD patients in the literatures.
Method: In this study, functional magnetic resonance imaging data were acquired for 22 AUD patients and 22 healthy controls with similar demographic characteristics. The functional connectivities between the regions in salience network was chosen as the region of interest (ROI), and the ROI to ROI analysis with time series signals was conducted. After that two-sample t test was performed.
Results: In the results, AUD patients exhibited increased functional connectivities in the right anterior insula - left supramarginal gyrus, the right supramarginal gyrus - left rostral prefrontal cortex, right supramarginal gyrus - right rostral prefrontal cortex, and right supramarginal gyrus - left supramarginal gyrus compared to healthy controls. The strengths of functional connectivity in these areas were linked to the severity of AUD measured by Alcohol Use Disorder Identification Test (AUDIT).
Conclusion: The results of the study suggest that abnormal incentive salience toward alcohol-related stimuli might be associated with the aberrant functional connectivities in salience network.
Application: The aberrant functional connectivities in salience network might apply for discrimination of AUD, and determination the severity of AUD as neuroimaging markers.
Background: Individuals with Alcohol Use Disorder (AUD) has shown significant attention and attraction to alcohol-related stimuli. The previous studies demonstrated the neuropsychological, physiological responses elicited by alcohol-related cue. These researches suggested the altered functional connectivities between brain areas related to incentive salience among AUD patients, but not yet fully explored the functional connectivities in salience network during resting-state among AUD patients in the literatures.
Method: In this study, functional magnetic resonance imaging data were acquired for 22 AUD patients and 22 healthy controls with similar demographic characteristics. The functional connectivities between the regions in salience network was chosen as the region of interest (ROI), and the ROI to ROI analysis with time series signals was conducted. After that two-sample t test was performed.
Results: In the results, AUD patients exhibited increased functional connectivities in the right anterior insula - left supramarginal gyrus, the right supramarginal gyrus - left rostral prefrontal cortex, right supramarginal gyrus - right rostral prefrontal cortex, and right supramarginal gyrus - left supramarginal gyrus compared to healthy controls. The strengths of functional connectivity in these areas were linked to the severity of AUD measured by Alcohol Use Disorder Identification Test (AUDIT).
Conclusion: The results of the study suggest that abnormal incentive salience toward alcohol-related stimuli might be associated with the aberrant functional connectivities in salience network.
Application: The aberrant functional connectivities in salience network might apply for discrimination of AUD, and determination the severity of AUD as neuroimaging markers.
목차
1. Introduction
2. Method
3. Results
4. Conclusion
References
참고문헌 (37)
참고문헌 신청
Bird, G / 2013 / Mixed emotions: The contribution of alexithymia to the emotional symptoms of autism / Translational Psychiatry 3(7):e285
Bottlender, M / 2005 / Outpatient alcoholism treatment: predictors of outcome after 3 years / Drug and Alcohol Dependence 80(1):83~89
Carter, R. M. / 2013 / A nexus model of the temporal-parietal junction / Trends in Cognitive Sciences 17(7):328~336
Cavanna, A. E. / 2006 / The precuneus: a review of its functional anatomy and behavioural correlates / Brain 129(3):564~583
최문종 / 2002 / 한국어판 강박음주 갈망척도의 표준화 연구 : 신뢰도와 타당도 / 신경정신의학 41(1)
Bottlender, M / 2005 / Outpatient alcoholism treatment: predictors of outcome after 3 years / Drug and Alcohol Dependence 80(1):83~89
Carter, R. M. / 2013 / A nexus model of the temporal-parietal junction / Trends in Cognitive Sciences 17(7):328~336
Cavanna, A. E. / 2006 / The precuneus: a review of its functional anatomy and behavioural correlates / Brain 129(3):564~583
최문종 / 2002 / 한국어판 강박음주 갈망척도의 표준화 연구 : 신뢰도와 타당도 / 신경정신의학 41(1)
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UCI(KEPA) : I410-ECN-0101-2020-530-000339849