지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 361 - 371 (11page)
- DOI
- 10.5143/JESK.2019.38.5.361
이용수
초록· 키워드
오류제보하기
Objective: The purpose of this study is to find brain areas shown a difference of the volume and cortical thickness between females with major depressive disorder (MDD) and healthy females.
Background: Although neuroimaging studies on the characteristics of MDD have been accumulating, limited studies have used both brain volume and cortical thickness to find the structural alteration in MDD. Integrating measures of structural brain imaging provide profound insights into the neurobiological underpinnings of MDD.
Method: Twenty-two females with MDD and 23 age- and sex-matched healthy females participated in this study. A 3T Philips Achieva MRI scanner (Philips Medical Systems, Best, The Netherlands) was used for image acquisition. Gray matter volume and cortical thickness were analyzed using voxel-based morphometry (VBM) and surface-based morphometry (SBM).
Results: VBM results indicated that individuals with MDD had significantly reduced gray matter volume in the anterior cingulate gyrus, hippocampus, hippocampal gyrus and precuneus and cerebellum compared to controls. Moreover, gray matter volume in the right anterior cingulate gyrus was negatively correlated with the severity of depression. SBM results demonstrated that compared to healthy controls, individuals with MDD showed reduced cortical thickness in temporal pole, paracentral gyrus, angular gyrus and insula.
Conclusion: These findings suggest that structural alterations in the anterior cingulate gyrus are linked to MDD, thereby providing understanding into the neural mechanisms underlying MDD.
Application: Alterations in the anterior cingulate cortex may act as neuroimaging markers of MDD, and these findings provide a possibility to developed the diagnosis system for MDD.
Background: Although neuroimaging studies on the characteristics of MDD have been accumulating, limited studies have used both brain volume and cortical thickness to find the structural alteration in MDD. Integrating measures of structural brain imaging provide profound insights into the neurobiological underpinnings of MDD.
Method: Twenty-two females with MDD and 23 age- and sex-matched healthy females participated in this study. A 3T Philips Achieva MRI scanner (Philips Medical Systems, Best, The Netherlands) was used for image acquisition. Gray matter volume and cortical thickness were analyzed using voxel-based morphometry (VBM) and surface-based morphometry (SBM).
Results: VBM results indicated that individuals with MDD had significantly reduced gray matter volume in the anterior cingulate gyrus, hippocampus, hippocampal gyrus and precuneus and cerebellum compared to controls. Moreover, gray matter volume in the right anterior cingulate gyrus was negatively correlated with the severity of depression. SBM results demonstrated that compared to healthy controls, individuals with MDD showed reduced cortical thickness in temporal pole, paracentral gyrus, angular gyrus and insula.
Conclusion: These findings suggest that structural alterations in the anterior cingulate gyrus are linked to MDD, thereby providing understanding into the neural mechanisms underlying MDD.
Application: Alterations in the anterior cingulate cortex may act as neuroimaging markers of MDD, and these findings provide a possibility to developed the diagnosis system for MDD.
목차
1. Introduction
2. Method
3. Results
4. Conclusion
References
참고문헌 (41)
참고문헌 신청
Ashburner, J. / 2000 / Voxel-based morphometry—the methods / Neuroimage 11(6):805~821
Ashburner, J. / 2007 / A fast diffeomorphic image registration algorithm / Neuroimage 38(1):95~113
Avery, J. A. / 2014 / Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula / Biological Psychiatry 76(3):258~266
Beck, A. T. / 1988 / An inventory for measuring clinical anxiety: psychometric properties / Journal of Consulting and Clinical Psychology 56(6):893
Bora, E. / 2012 / Gray matter abnormalities in major depressive disorder: a meta-analysis of voxelbased morphometry studies / Journal of Affective Disorders 138(1-2):9~18
Ashburner, J. / 2007 / A fast diffeomorphic image registration algorithm / Neuroimage 38(1):95~113
Avery, J. A. / 2014 / Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula / Biological Psychiatry 76(3):258~266
Beck, A. T. / 1988 / An inventory for measuring clinical anxiety: psychometric properties / Journal of Consulting and Clinical Psychology 56(6):893
Bora, E. / 2012 / Gray matter abnormalities in major depressive disorder: a meta-analysis of voxelbased morphometry studies / Journal of Affective Disorders 138(1-2):9~18
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UCI(KEPA) : I410-ECN-0101-2020-530-000339758