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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.46 No.4
- 발행연도
- 2019.12
- 수록면
- 885 - 895 (11page)
이용수
초록· 키워드
오류제보하기
Plant biotechnologists have long dreamed of technologies to manipulate genes in plants at will. This dream has come true partly through the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology, which now has been used to edit genes in several important crops. However, there are many restrictions in editing a gene precisely using the CRISPR/Cas9 technology because CRISPR/Cas9 may cause deletions or additions in some regions of the target gene. Several other technologies have been developed for gene targeting and precision editing. Among these, base editors might be the most practically and efficiently used compared to others. Base editors are tools which are able to cause a transition from cytosine into thymine, or from adenine into guanine very precisely on specific sequences. Cytosine base editors basically consist of nCas9, cytosine deaminase, and uracil DNA glycosylase inhibitor (UGI). Adenine base editors consist of nCas9 and adenine deaminase. These were first developed for human cells and have since also been applied successfully to crops. Base editors have been successfully applied for productivity improvement, fortification and herbicide resistance of crops. Thus, base editor technologies start to open a new era for precision gene editing or breeding in crops and might result in revolutionary changes in crop breeding and biotechnology.
목차
Abstract
Introduction
Cas9 핵산분해 효소 활성 돌연변이 개발
Cytosine base editor (CBE)의 개발 및 식물용 CBE의 개발
Adenine base editor (ABE)의 개발 및 식물용 ABE의 개발
PAM 염기서열 및 염기교정 범위의 확장
Base editor를 이용한 작물 염기교정 사례 및 전망
염기교정기술의 농업적 활용 전망
Conclusion
References
참고문헌 (37)
참고문헌 신청
Barrangou R / 2007 / CRISPR provides acquired resistance against viruses in prokaryotes / Science 315:1709~1712
Belhaj K / 2015 / Editing plant genomes with CRISPR/Cas9 / Current Opinion Biotechnology 32:76~84
Cong L / 2013 / Multiplex genome engineering using CRISPR/Cas systems / Science 339:819~823
Endo M / 2019 / Genome editing in plants by engineered CRISPR-Cas9 recognizing NG PAM / Nature Plants 5:14~17
Gaudelli NM / 2017 / Programmable base editing of A*T to G*C in genomic DNA without DNA cleavage / Nature 551:464~471
Belhaj K / 2015 / Editing plant genomes with CRISPR/Cas9 / Current Opinion Biotechnology 32:76~84
Cong L / 2013 / Multiplex genome engineering using CRISPR/Cas systems / Science 339:819~823
Endo M / 2019 / Genome editing in plants by engineered CRISPR-Cas9 recognizing NG PAM / Nature Plants 5:14~17
Gaudelli NM / 2017 / Programmable base editing of A*T to G*C in genomic DNA without DNA cleavage / Nature 551:464~471
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