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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 363 - 375 (13page)
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초록· 키워드
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Fungal sectorization is a complex trait that is still not fully understood. The unique phenotypic changes in sporadic sectorization in mutants of CpBck1, a mitogen-activated protein kinase kinase kinase (MAPKKK) gene, and CpSlt2, a itogenactivated protein kinase (MAPK) gene, in the cell wall integrity pathway of the chestnut blight fungus Cryphonectria parasitica have been previously studied. Although several environmental and physiological factors cause this sectoring phenotype, genetic variants can also impact this complex morphogenesis. Therefore, RNA sequencing analysis was employed to identify candidate genes associated with sectorization traits and understand the genetic mechanism of this phenotype. Transcriptomic analysis of CpBck1 and CpSlt2 mutants and their sectored progeny strains revealed a number of differentially expressed genes (DEGs) related to various cellular processes. Approximately 70% of DEGs were common between the wild-type and each of CpBck1 and CpSlt2 mutants, indicating that CpBck1 and CpSlt2 are components of the same MAPK pathway, but each component governs specific sets of genes. Functional description of the DEGs between the parental mutants and their sectored progenies revealed several key pathways, including the biosynthesis of secondary metabolites, translation, amino acid metabolism, and carbohydrate metabolism; among these, pathways for secondary metabolism and translation appeared to be the most common pathway. The results of this comparative study provide a better understanding of the genetic regulation of sector formation and suggest that complex several regulatory pathways result in interplays between secondary metabolites and morphogenesis.
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참고문헌 (34)
참고문헌 신청
Allen, T. D. / 2003 / Use of cDNA microarrays to monitor transcriptional responses of the chestnut blight fungus Cryphonectria parasitica to infection by virulenceattenuating hypoviruses / Eukaryot. Cell 2:1253~1265
Anders, S. / 2010 / Differential expression analysis of sequence count data / Genome Biol 11:106~110
Bhatti, M. F. / 2011 / The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus / Fungal Genet. Biol 48:1071~1075
Bowman, S. M. / 2006 / The structure and synthesis of the fungal cell wall / Bioessays 28:799~808
undefined / 2017 / Analysis of Genes with Alternatively Spliced Transcripts in the Leaf, Root, Panicle and Seed of Rice Using a Long Oligomer Microarray and RNA-Seq / Molecules and Cells
Anders, S. / 2010 / Differential expression analysis of sequence count data / Genome Biol 11:106~110
Bhatti, M. F. / 2011 / The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus / Fungal Genet. Biol 48:1071~1075
Bowman, S. M. / 2006 / The structure and synthesis of the fungal cell wall / Bioessays 28:799~808
undefined / 2017 / Analysis of Genes with Alternatively Spliced Transcripts in the Leaf, Root, Panicle and Seed of Rice Using a Long Oligomer Microarray and RNA-Seq / Molecules and Cells
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