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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 328 - 333 (6page)
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Background and Purpose Alemtuzumab has shown high efficacy in clinical trials that primarily involved Western multiple sclerosis (MS) patients. To evaluate the therapeutic outcome of alemtuzumab in Korean patients with MS. Methods This study enrolled 23 consecutive patients who were treated with alemtuzumab from 2015 to 2018. Efficacy was evaluated using the annualized relapse rate (ARR), Expanded Disability Status Scale (EDSS), and radiological activity. No evidence of disease activity (NEDA) was defined as no clinical relapse, no worsening of the EDSS score, and no radiological activity. The safety profiles were also assessed. Results The mean age was 36 years and 16 of the patients were female. Seventeen and 12 of 23 patients were followed up for 1 year and 2 years, respectively. The ARR was markedly reduced from 1.52 during the 1-year period preceding alemtuzumab administration to 0.21 after initiating alemtuzumab (p<0.001). During the first and second years after initiating alemtuzumab, EDSS worsening was observed in 3 (18%) and 0 (0%) patients, respectively, and radiological activity was exhibited in 9 (53%) and 4 (33%). NEDA was observed in 6 (35%) patients during the first year and in 8 (67%) patients during the second year. Intriguingly, one patient experienced 2 severe clinical exacerbations, which occurred at 10 months after the first and 10 months after the second infusion of alemtuzumab. Nineteen of the 23 patients exhibited infusion-associated reactions and 3 patients exhibited herpes zoster infection. Thyroid dysfunction occurred in two patients at 18 and 20 months after initiating alemtuzumab. Conclusions Consistent with observations in Western populations, alemtuzumab therapy in Korean MS patients led to marked reductions of disease activity without unexpected safety issues.
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참고문헌 (23)
참고문헌 신청
Cox AL / 2005 / Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis / Eur J Immunol 35:3332~3342
CAMMS223 Trial Investigators / 2008 / interferon beta-1a in early multiple sclerosis / N Engl J Med 359:1786~1801
Cohen JA / 2012 / Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis : a randomised controlled phase 3 trial / Lancet 380:1819~1828
Havrdova E / 2017 / Alemtuzumab CARE-MS I 5-year follow-up : durable efficacy in the absence of continuous MS therapy / Neurology 89:1107~1116
Coles AJ / 2012 / Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy : a randomised controlled phase 3 trial / Lancet 380:1829~1839
CAMMS223 Trial Investigators / 2008 / interferon beta-1a in early multiple sclerosis / N Engl J Med 359:1786~1801
Cohen JA / 2012 / Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis : a randomised controlled phase 3 trial / Lancet 380:1819~1828
Havrdova E / 2017 / Alemtuzumab CARE-MS I 5-year follow-up : durable efficacy in the absence of continuous MS therapy / Neurology 89:1107~1116
Coles AJ / 2012 / Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy : a randomised controlled phase 3 trial / Lancet 380:1829~1839
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