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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 313 - 320 (8page)
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Intraepithelial lymphocytes (IELs) develop through the continuous interaction with intestinal antigens such as commensal microbiome and diet. However, their respective roles and mutual interactions in the development of IELs are largely unknown. Here, we showed that dietary antigens regulate the development of the majority of CD8αβ IELs in the small intestine and the absence of commensal microbiota particularly during the weaning period, delay the development of IELs. When we tested specific dietary components, such as wheat or combined corn, soybean and yeast, they were dependent on commensal bacteria for the timely development of diet-induced CD8αβ IELs. In addition, supplementation of intestinal antigens later in life was inefficient for the full induction of CD8αβ IELs. Overall, our findings suggest that early exposure to commensal bacteria is important for the proper development of dietary antigen-dependent immune repertoire in the gut.
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참고문헌 (37)
참고문헌 신청
Abadie, V. / 2012 / Intraepithelial lymphocytes in celiac disease immunopathology / Semin. Immunopathol 34:551~566
Anderson, K. G. / 2014 / Intravascular staining for discrimination of vascular and tissue leukocytes / Nat. Protoc 9:209~222
Anderson, K. G. / 2012 / Cutting edge : intravascular staining redefines lung CD8 T cell responses / J. Immunol 189:2702~2706
Bol-Schoenmakers, M. / 2011 / Regulation by intestinal gammadelta T cells during establishment of food allergic sensitization in mice / Allergy 66:331~340
Buzoni-Gatel, D. / 1999 / Intraepithelial lymphocytes traffic to the intestine and enhance resistance to Toxoplasma gondii oral infection / J. Immunol 162:5846~5852
Anderson, K. G. / 2014 / Intravascular staining for discrimination of vascular and tissue leukocytes / Nat. Protoc 9:209~222
Anderson, K. G. / 2012 / Cutting edge : intravascular staining redefines lung CD8 T cell responses / J. Immunol 189:2702~2706
Bol-Schoenmakers, M. / 2011 / Regulation by intestinal gammadelta T cells during establishment of food allergic sensitization in mice / Allergy 66:331~340
Buzoni-Gatel, D. / 1999 / Intraepithelial lymphocytes traffic to the intestine and enhance resistance to Toxoplasma gondii oral infection / J. Immunol 162:5846~5852
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