지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 603 - 610 (8page)
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초록· 키워드
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Purpose This study aimed to report the clinical outcomes following selective neck irradiation (SNI) with lower elective radiation therapy (RT) dose in treating nasopharyngeal cancer (NPC) patients. Materials and Methods A total of 347 NPC patients received definitive RT according to our SNI policy and were retrospectively analyzed. The clinical target volumes (CTVs) were subdivided into CTV at high risk (CTV-HR) and CTV at low risk (CTV-LR). The typical doses to gross tumor volume (GTV), CTV-HR, and CTV-LR were 68.4-70.0 Gy, 54.0-60.0 Gy, and 36.0 Gy. Results With the median follow-up of 68.1 months (range, 2.3 to 197.1 months), the 5-year rates of loco-regional control and progression-free survival in all the patients were 85.0% and 70.8%, respectively. Thirty patients developed regional failure and the regional control rates at 3 and 5 years were 92.6% and 91.4%, respectively. The sites of regional failure in relation to the target volume were exclusively inside GTV/CTV-HR in 20, inside and outside GTV/CTVHR in three, and exclusively outside GTV/CTV-HR in seven, which were 5.7%, 0.9%, and 2.0% of total patients, respectively. Conclusion The clinical outcomes by the current SNI policy were feasible and comparable to those following classic elective nodal irradiation policy.
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참고문헌 (30)
참고문헌 신청
Lee AW / 2010 / Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma / J Natl Cancer Inst 102:1188~1198
Ou SH / 2007 / Epidemiology of nasopharyngeal carcinoma in the United States : improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology / Ann Oncol 18:29~35
Ho FC / 2012 / Patterns of regional lymph node metastasis of nasopharyngeal carcinoma : a meta-analysis of clinical evidence / BMC Cancer 12:98
Lee AW / 1989 / Treatment of stage I nasopharyngeal carcinoma : analysis of the patterns of relapse and the results of withholding elective neck irradiation / Int J Radiat Oncol Biol Phys 17:1183~1190
Fletcher GH / 1972 / Elective irradiation of subclinical disease in cancers of the head and neck / Cancer 29:1450~1454
Ou SH / 2007 / Epidemiology of nasopharyngeal carcinoma in the United States : improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology / Ann Oncol 18:29~35
Ho FC / 2012 / Patterns of regional lymph node metastasis of nasopharyngeal carcinoma : a meta-analysis of clinical evidence / BMC Cancer 12:98
Lee AW / 1989 / Treatment of stage I nasopharyngeal carcinoma : analysis of the patterns of relapse and the results of withholding elective neck irradiation / Int J Radiat Oncol Biol Phys 17:1183~1190
Fletcher GH / 1972 / Elective irradiation of subclinical disease in cancers of the head and neck / Cancer 29:1450~1454
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