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Purpose: This study aims to develop a multi-purpose electron beam irradiation device for preclinical research and material testing using the research electron linear accelerator installed at the Dongnam Institute of Radiological and Medical Sciences. Methods: The fabricated irradiation device comprises a dual scattering foil and collimator. The correct scattering foil thickness, in terms of the energy loss and beam profile uniformity, was determined using Monte Carlo calculations. The ion-chamber and radiochromic films were used to determine the reference dose-rate (Gy/s) and beam profiles as functions of the source to surface distance (SSD) and pulse frequency. Results: The dose-rates for the electron beams were evaluated for the range from 59.16 Gy/s to 5.22 cGy/s at SSDs of 40一120 cm, by controlling the pulse frequency. Furthermore, uniform dose distributions in the electron fields were achieved up to approximately 10 cm in diameter. An empirical formula for the systematic dose-rate calculation for the irradiation system was established using the measured data. Conclusions: A wide dose-rate range electron beam irradiation device was successfully developed in this study. The pre-clinical studies relating to FLASH radiotherapy to the conventional level were made available. Additionally, material studies were made available using a quantified irradiation system. Future studies are required to improve the energy, dose-rate, and field uniformity of the irradiation system.
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참고문헌 (16)
참고문헌 신청
Lim H / 2016 / Design of a radiotherapy machine using the 6 MeV C-band standingwave accelerator / Paper presented at: International Particle Accelerator Conference (IPAC) 2016 :1921~1923
Lim H / 2016 / Control system of the C-band standing-wave accelerator for the medical application / Paper presented at: International Particle Accelerator Conference (IPAC) 2016 :4104~4106
Lim H / 2018 / Status of the DIRAMS C-band standing-wave accelerator for a radiotherapy machine / Paper presented at: 9th Asia Forum for Accelerators and Detectors :28~31
Kang SK / 2019 / Dosimetry system for medical and biological applications of the electron linear accelerator / Paper presented at: The 23rd International Conference on Accelerators and Beam Utilization (ICABU2019) :153
Kyoung Won Jang / 2020 / Monte Carlo Simulation of an Electron Irradiation Device for Medical Application of an Electron Linear Accelerator / Journal of the Korean Physical Society 76(7):588~591
Lim H / 2016 / Control system of the C-band standing-wave accelerator for the medical application / Paper presented at: International Particle Accelerator Conference (IPAC) 2016 :4104~4106
Lim H / 2018 / Status of the DIRAMS C-band standing-wave accelerator for a radiotherapy machine / Paper presented at: 9th Asia Forum for Accelerators and Detectors :28~31
Kang SK / 2019 / Dosimetry system for medical and biological applications of the electron linear accelerator / Paper presented at: The 23rd International Conference on Accelerators and Beam Utilization (ICABU2019) :153
Kyoung Won Jang / 2020 / Monte Carlo Simulation of an Electron Irradiation Device for Medical Application of an Electron Linear Accelerator / Journal of the Korean Physical Society 76(7):588~591
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