지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제1호
- 발행연도
- 2017.1
- 수록면
- 53 - 58 (6page)
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초록· 키워드
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Objective: CDKN2B-AS1 polymorphisms were shown to associate with the risk of stroke in European. The goal of this study was to evaluate the contribution of CDKN2B-AS1 rs1333049 to the risk of hemorrhagic stroke (HS) and brain tumor (BT) in Han Chinese.
Methods: A total of 142 HSs, 115 BTs, and 494 controls were included in the current association study. The genotyping test was performed using the melting temperature shift method.
Results: We failed to validate the association of CDKN2B-AS1 rs1333049 with the risk of brain disease. Significantly higher levels of low-density lipoprotein cholesterol (LDL-C) (p=0.027), high-density lipoprotein cholesterol (HDL-C) (p＜0.001) and total cholesterol (TC) (p＜0.001) were found in HSs in the genotype GG/GC carriers, but not the genotype CC carriers (p＞0.05). The meta-analysis of 10 studies among 133,993 individuals concluded that rs1333049 of CDKN2B-AS1 gene was likely to increase a 16% incidence rate of cerebrovascular disease (CD) among various populations (odds ratio 1.16, 95% confidence interval 1.08-1.25; p＜0.0001, random-effect method).
Conclusion: Our case-control study identified rs1333049 genotypes showed different association with the concentration of the LDL-C, HDL-C and TC in the HS patients. Meta-analysis supported the association between rs1333049 and CD risk in various populations, although we were unable to observe association between rs1333049 and the risk of HSs in Han Chinese.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Adel Fahmideh M / 2015 / CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility / Carcinogenesis 36 : 876 ~ 882
Bai Y / 2014 / Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211(p.C10X) with ischemic stroke / Stroke 45 : 383 ~ 388
Bayoglu B / 2016 / Polymorphisms in the long non-coding RNA CDKN2B-AS1 may contribute to higher systolic blood pressure levels in hypertensive patients / Clin Biochem 49 : 82
Bochenek G / 2013 / The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF1
Cunnington MS / 2010 / Chromosome 9p21 SNPs associated with multiple disease phenotypes correlate with ANRIL Expression / PLoS Genet 6 : e1000899 ~
Bai Y / 2014 / Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211(p.C10X) with ischemic stroke / Stroke 45 : 383 ~ 388
Bayoglu B / 2016 / Polymorphisms in the long non-coding RNA CDKN2B-AS1 may contribute to higher systolic blood pressure levels in hypertensive patients / Clin Biochem 49 : 82
Bochenek G / 2013 / The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF1
Cunnington MS / 2010 / Chromosome 9p21 SNPs associated with multiple disease phenotypes correlate with ANRIL Expression / PLoS Genet 6 : e1000899 ~
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