지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제4호
- 발행연도
- 2019.1
- 수록면
- 587 - 595 (9page)
이용수
초록· 키워드
오류제보하기
Pharmacological research on (CHA), a marine-derived quinazolinone alkaloid with significant cytotoxic activity, is restricted by low yields and is a problem that needs to be settled urgently. In this work, the selection of additional nitrogen sources and the optimization of additional concentrations and longer fermentation times using ammonium acetate, were investigated. CHA production was optimized to 62.1 mg/l with the addition of 50 mM ammonium acetate at 120 h of the fermentation in the shaker flask. This feeding strategy significantly increased 3- deoxy-arabino-heptulosonate-7-phosphate synthase activity and transcript levels of critical genes (laeA, dahp, and trpC) in the shikimate pathway compared with the non-treatment group. In addition, the selection of the feeding rate (0.01 and 0.03 g/l·h) was investigated in a 5-L bioreactor. As a result, CHA production was increased by 57.9 mg/l with a 0.01 g/l·h ammonium acetate feeding rate. This work shows that the strategy of ammonium acetate supplementation had an effective role in improving CHA production by Aspergillus fumigatus CY018. It also shows that this strategy could serve as an important example of large-scale fermentation of a marine fungus in submerged culture.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Sashidhara KV / 2009 / A Selective Account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products / J. Nat. Prod 72:588~603
Liao L / 2017 / Asperphenins A and B, lipopeptidyl benzophenones from a marine-derived Aspergillus sp / Fungus. Org. Lett 19:2066~2069
Wang X / 2018 / Bioactive pimarane-type diterpenes from marine organisms / Chem. Biodivers 15:e1700276
Duarte K / 2012 / Analytical techniques for discovery of bioactive compounds from marine fungi / Trends Analyt. Chem 34:97~110
Ulrike Lindequist / 2016 / Marine-Derived Pharmaceuticals – Challenges and Opportunities / Biomolecules & Therapeutics 24(6):561~571
Liao L / 2017 / Asperphenins A and B, lipopeptidyl benzophenones from a marine-derived Aspergillus sp / Fungus. Org. Lett 19:2066~2069
Wang X / 2018 / Bioactive pimarane-type diterpenes from marine organisms / Chem. Biodivers 15:e1700276
Duarte K / 2012 / Analytical techniques for discovery of bioactive compounds from marine fungi / Trends Analyt. Chem 34:97~110
Ulrike Lindequist / 2016 / Marine-Derived Pharmaceuticals – Challenges and Opportunities / Biomolecules & Therapeutics 24(6):561~571
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hygroscopicity of Particles Contained Ammonium Sulfate and Ammonium Nitrate
한국대기환경학회 학술대회논문집
2020 .10
-
암모늄 이온의 질소 안정동위원소 조성 분석법
대한지질학회 학술대회
2015 .10
-
Systematic Study on Hygroscopic Behavior of Ammonium Sulfate and Ammonium Nitrate Mixture Particles
한국대기환경학회 학술대회논문집
2017 .11
-
Increased Production of Ginsenoside Compound K by Optimizing the Feeding of American Ginseng Extract during Fermentation by Aspergillus tubingensis
Journal of Microbiology and Biotechnology
2022 .07
-
서울 PM2.5 질산염과 암모늄의 질소 및 산소 동위원소 분석
한국대기환경학회 학술대회논문집
2019 .11
-
Analysis of nitrogen isotopic composition of ammonium ion using the ammonium diffusion technique
지질학회지
2016 .04
-
Transcription Factor OsDOF18 Controls Ammonium Uptake by Inducing Ammonium Transporters in Rice Roots
Molecules and Cells
2017 .03
-
Aspergillus fumigatus 에 의한 휘발성유기화합물 분해
한국대기환경학회 학술대회논문집
2017 .11
-
Analysis of 15N-NH₄+ stable isotope using ammonium diffusion technique
한국분석과학회 학술대회
2022 .05
-
Mineral nitrogen isotope signature in clay minerals formed under high ammonium environment conditions in sediment associated with ammonium-rich sediment-hosted hydrothermal system
대한지질학회 학술대회
2018 .10
-
PM2.5 질산염 및 암모늄 분배의 지역별 특성 및 기상영향 분석
한국대기환경학회 학술대회논문집
2023 .10
-
Role of Signal Peptidase in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2022 .10
-
Expression Patterns of Developmental Genes during Mating in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2019 .04
-
Preparation of Cellulose Acetate Produced from Lignocellulosic Biomass
목재공학(Journal of the Korean Wood Science and Technology)
2016 .01
-
Fungal Fermentation of Lignocellulosic Biomass for Itaconic and Fumaric Acid Production
Journal of Microbiology and Biotechnology
2017 .01
-
측정 시 발생하는 질산암모늄 증발을 고려한 서울지역 PM2.5의 암모니아 배출 저감 민감도 평가
한국대기환경학회 학술대회논문집
2021 .10
-
막걸리 발효조건에 따른 isoamyl acetate 생성 비교
생명과학회지
2020 .02
-
Iron and Copper Metabolisms are Closely Connected and Interdependent; Look into Their Relationship in Aspergillus fumigatus
한국미생물학회 학술대회논문집
2018 .04
-
An Environmentally Friendly and Efficient Method for Extraction of PHB Biopolymer with Non-Halogenated Solvents
Journal of Microbiology and Biotechnology
2015 .01
-
Simultaneous determination of sub-μg/L sodium in the presence of mg/l level ammonium and ethanolamine in power plant water by suppressed ion chromatography
한국분석과학회 학술대회
2016 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0