지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 24 - 34 (11page)
이용수
초록· 키워드
오류제보하기
Sirtuin is an essential factor that delays cellular senescence and extends the organismal lifespan through the regulation of diverse cellular processes. Suppression of cellular senescence by Sirtuin is mainly mediated through delaying the age-related telomere attrition, sustaining genome integrity and promotion of DNA damage repair. In addition, Sirtuin modulates the organismal lifespan by interacting with several lifespan regulating signaling pathways including insulin/IGF-1 signaling pathway, AMP-activated protein kinase, and forkhead box O. Although still controversial, it is suggested that the prolongevity effect of Sirtuin is dependent with the level of and with the tissue expression of Sirtuin. Since Sirtuin is also believed to mediate the prolongevity effect of calorie restriction, activators of Sirtuin have attracted the attention of researchers to develop therapeutics for age-related diseases. Resveratrol, a phytochemical rich in the skin of red grapes and wine, has been actively investigated to activate Sirtuin activity with consequent beneficial effects on aging. This article reviews the evidences and controversies regarding the roles of Sirtuin on cellular senescence and lifespan extension, and summarizes the activators of Sirtuin including Sirtuin-activating compounds and compounds that increase the cellular level of nicotinamide dinucleotide.
목차
등록된 정보가 없습니다.
참고문헌 (145)
참고문헌 신청
North BJ / 2004 / Sirtuins : Sir2-related NAD-dependent protein deacetylases / Genome Biol 5:224
Toiber D / 2011 / Characterization of nuclear sirtuins : molecular mechanisms and physiological relevance / Handb Exp Pharmacol 206:189~224
Guarente L / 2000 / Sir2 links chromatin silencing, metabolism, and aging / Genes Dev 14:1021~1026
Kaeberlein M / 1999 / The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms / Genes Dev 13:2570~2580
Imai S / 2000 / Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase / Nature 403:795~800
Toiber D / 2011 / Characterization of nuclear sirtuins : molecular mechanisms and physiological relevance / Handb Exp Pharmacol 206:189~224
Guarente L / 2000 / Sir2 links chromatin silencing, metabolism, and aging / Genes Dev 14:1021~1026
Kaeberlein M / 1999 / The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms / Genes Dev 13:2570~2580
Imai S / 2000 / Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase / Nature 403:795~800
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Mechanisms and disease implications of sirtuin-mediated autophagic regulation
Experimental and Molecular Medicine
2019 .01
-
MicroRNA controls of cellular senescence
BMB Reports
2018 .01
-
Cellular senescence: a promising strategy for cancer therapy
BMB Reports
2019 .01
-
Cellular senescence, aging, and age-related disease: Special issue of BMB Reports in 2019
BMB Reports
2019 .01
-
Juxtacrine regulation of cellular senescence
BMB Reports
2019 .01
-
Cellular V2X를 고려한 네트워크 시뮬레이션에 대한 연구
한국통신학회 학술대회논문집
2019 .01
-
Alternative Polyadenylation(APA)-mediated 3’UTR Lengthening Contributes to Cellular Senescence
한국생물공학회 학술대회
2023 .04
-
Disruption of nucleocytoplasmic trafficking as a cellular senescence driver
Experimental and Molecular Medicine
2021 .06
-
Annexin A2 as a regulator of the cellular senescence and apoptosis through p21
한국생물공학회 학술대회
2015 .04
-
Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair
BMB Reports
2024 .02
-
From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes
BMB Reports
2015 .01
-
The role of BCAA metabolism in metabolic health and disease
Experimental and Molecular Medicine
2024 .07
-
Metabolic features and regulation in cell senescence
BMB Reports
2019 .01
-
Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence
BMB Reports
2017 .01
-
Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications
Experimental and Molecular Medicine
2019 .01
-
Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation
BMB Reports
2019 .01
-
Cellular IoT 를 위한 데이터 전송 방법
한국통신학회 학술대회논문집
2020 .11
-
TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency
Experimental and Molecular Medicine
2020 .01
-
Links between accelerated replicative cellular senescence and down-regulation of SPHK1 transcription
BMB Reports
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0