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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 424 - 433 (10page)
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초록· 키워드
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Autism spectrum disorder (ASD) is a complex neurodevelopmental monogenic disorder with a strong genetic influence. Idiopathic autism could be defined as a type of autism that does not have a specific causative agent. Among signalling cascades, mTOR signalling pathway plays a pivotal role not only in cell cycle, but also in protein synthesis and regulation of brain homeostasis in ASD patients. The present review highlights, underlying mechanism of mTOR and its role in altered signalling cascades as a triggering factor in the onset of idiopathic autism. Further, this review discusses how distorted mTOR signalling pathway stimulates truncated translation in neuronal cells and leads to downregulation of protein synthesis at dendritic spines of the brain. This review concludes by suggesting downstream regulators such as p70S6K, eIF4B, eIF4E of mTOR signalling pathway as promising therapeutic targets for idiopathic autistic individuals.
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등록된 정보가 없습니다.
참고문헌 (92)
참고문헌 신청
Al-Zahrani A / 2013 / Prevalence and clinical characteristics of autism spectrum disorders in school-age children in Taif-KSA / Int J Med Sci Public Health 2:578~582
Gilbert J / 2017 / Fundamental elements in autism : from neurogenesis and neurite growth to synaptic plasticity / Front Cell Neurosci 11:359
Jiang YH / 2014 / Genetic diagnosis of autism spectrum disorders : the opportunity and challenge in the genomics era / Crit Rev Clin Lab Sci 51:249~262
Mattila ML / 2011 / Autism spectrum disorders according to DSM-IV-TR and comparison with DSM-5 draft criteria : an epidemiological study / J Am Acad Child Adolesc Psychiatry 50:583~592
Harker CM / 2014 / Comparison of the Diagnostic Criteria for Autism Spectrum Disorder Across DSM-5, DSM-IV-TR, 2 and the Individuals with Disabilities Act (IDEA) 3 Definition of Autism :1~6
Gilbert J / 2017 / Fundamental elements in autism : from neurogenesis and neurite growth to synaptic plasticity / Front Cell Neurosci 11:359
Jiang YH / 2014 / Genetic diagnosis of autism spectrum disorders : the opportunity and challenge in the genomics era / Crit Rev Clin Lab Sci 51:249~262
Mattila ML / 2011 / Autism spectrum disorders according to DSM-IV-TR and comparison with DSM-5 draft criteria : an epidemiological study / J Am Acad Child Adolesc Psychiatry 50:583~592
Harker CM / 2014 / Comparison of the Diagnostic Criteria for Autism Spectrum Disorder Across DSM-5, DSM-IV-TR, 2 and the Individuals with Disabilities Act (IDEA) 3 Definition of Autism :1~6
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