지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find biomarkers. Most metabolome-related ischemic stroke studies were done in Asia and had exploratory designs. Although failed to find specific biomarkers, they discovered several important metabolite-stroke associations which belong to three pathophysiological mechanisms: Excitotoxicity with activation of glutamate, resulting in the increase of glutamate derivatives proline and pyroglutamate; Oxidative stress with production of free radicals and perturbed concentrations of uric acid, matrix metalloproteinase-9, branch-chained amino acids, sphingolipids, homocysteine, asymmetric dimethylarginine, nitric oxide and folate cycle metabolites; and Stroke mediated inflammation, affecting phospholipid metabolism with perturbed levels of lysophosphatidylethanolamine and lysophosphatidylcholine. The discovered metabolite-stroke associations need further evaluation in prospective, high-quality studies with patients matched for age, risk factors, and medications.
목차
등록된 정보가 없습니다.
참고문헌 (85)
참고문헌 신청
Powers WJ / 2018 / 2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association / Stroke 49:e46~e110
Tsai CF / 2013 / Epidemiology of stroke and its subtypes in Chinese vs white populations: a systematic review / Neurology 81:264~272
Nogueira RG / 2018 / Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct / N Engl J Med 378:11~21
Albers GW / 2018 / Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging / N Engl J Med 378:708~718
Lansberg MG / 2009 / Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis / Stroke 40:2438~2441
Tsai CF / 2013 / Epidemiology of stroke and its subtypes in Chinese vs white populations: a systematic review / Neurology 81:264~272
Nogueira RG / 2018 / Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct / N Engl J Med 378:11~21
Albers GW / 2018 / Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging / N Engl J Med 378:708~718
Lansberg MG / 2009 / Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis / Stroke 40:2438~2441
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