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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Cerebral small vessel disease (CSVD) is a common group of neurological conditions that confer a significant burden of morbidity and mortality worldwide. In most cases, CSVD is only recognized in its advanced stages once its symptomatic sequelae develop. However, its significance in asymptomatic healthy populations remains poorly defined. In population-based studies of presumed healthy elderly individuals, CSVD neuroimaging markers including white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, cortical superficial siderosis, and cerebral microinfarcts are frequently detected. While the presence of these imaging markers may reflect unique mechanisms at play, there are likely shared pathways underlying CSVD. Herein, we aim to assess the etiology and significance of these individual biomarkers by focusing in asymptomatic populations at an epidemiological level. By primarily examining population-based studies, we explore the risk factors that are involved in the formation and progression of these biomarkers. Through a critical semi-systematic review, we aim to characterize “asymptomatic” CSVD, review screening modalities, and draw associations from observational studies in clinical populations. Lastly, we highlight areas of research (including therapeutic approaches) in which further investigation is needed to better understand asymptomatic CSVD.
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참고문헌 (207)
참고문헌 신청
Berkhemer OA / 2015 / A randomized trial of intraarterial treatment for acute ischemic stroke / N Engl J Med 372:11~20
Campbell BC / 2015 / Endovascular therapy for ischemic stroke with perfusion-imaging selection / N Engl J Med 372:1009~1018
Jovin TG / 2015 / Thrombectomy within 8 hours after symptom onset in ischemic stroke / N Engl J Med 372:2296~2306
Saver JL / 2015 / Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke / N Engl J Med 372:2285~2295
Bracard S / 2016 / Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke(THRACE) : a randomised controlled trial / Lancet Neurol 15:1138~1147
Campbell BC / 2015 / Endovascular therapy for ischemic stroke with perfusion-imaging selection / N Engl J Med 372:1009~1018
Jovin TG / 2015 / Thrombectomy within 8 hours after symptom onset in ischemic stroke / N Engl J Med 372:2296~2306
Saver JL / 2015 / Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke / N Engl J Med 372:2285~2295
Bracard S / 2016 / Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke(THRACE) : a randomised controlled trial / Lancet Neurol 15:1138~1147
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