지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 187 - 195 (9page)
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초록· 키워드
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Background and Purpose The recently developed total cerebral small-vessel disease (CSVD) score might appropriately reflect the total burden or severity of CSVD. We investigated whether the total CSVD score is associated with long-term outcomes during follow-up in patients with acute ischemic stroke.
Methods In total, 1,096 consecutive patients with acute ischemic stroke who underwent brain magnetic resonance imaging were enrolled. We calculated the total CSVD score for each patient after determining the burden of cerebral microbleeds (CMBs), high-grade white-matter hyperintensities (HWHs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs). We recorded the date and cause of death for all of the patients using data from the Korean National Statistical Office. We compared the long-term mortality rate with the total CSVD score using Cox proportional-hazards models.
Results CMBs were found in 26.8% of the subjects (294/1,096), HWHs in 16.4% (180/1,096), HPVSs in 19.3% (211/1,096), and ALIs in 38.0% (416/1,096). After adjusting for age, sex, and variables that were significant at p<0.1 in the univariate analysis, the total CSVD score was independently associated with long-term death from all causes [hazard ratio (HR)=1.18 per point, 95% confidence interval (CI)=1.07–1.30], ischemic stroke (HR=1.20 per point, 95% CI=1.01–1.42), and hemorrhagic stroke (HR=2.05 per point, 95% CI=1.30–3.22), but not with fatal cardiovascular events (HR=1.17 per point, 95% CI=0.82–1.67).
Conclusions The total CSVD score is a potential imaging biomarker for predicting mortality during follow-up in patients with acute ischemic stroke.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
[학술지(정기간
Adachi T / 2002 / Frequency and pathogenesis of silent subcortical brain infarction in acute first-ever ischemic stroke / Intern Med 41 : 103 ~ 108
Adams HP Jr / 1993 / Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172in Acute Stroke Treatm
Altmann-Schneider I / 2011 / Cerebral microbleeds are predictive of mortality in the elderly / Stroke 42 : 638 ~ 644
Arsava EM / 2009 / Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke / Neurology 72 : 1403 ~ 1410
Adachi T / 2002 / Frequency and pathogenesis of silent subcortical brain infarction in acute first-ever ischemic stroke / Intern Med 41 : 103 ~ 108
Adams HP Jr / 1993 / Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172in Acute Stroke Treatm
Altmann-Schneider I / 2011 / Cerebral microbleeds are predictive of mortality in the elderly / Stroke 42 : 638 ~ 644
Arsava EM / 2009 / Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke / Neurology 72 : 1403 ~ 1410
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