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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 181 - 189 (9page)
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초록· 키워드
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Cancer remains a life-threatening disease and accounts for the major mortality rates worldwide. The practice of using biomarkers for early detection, staging, and customized therapy may increase cancer patients’ survival. Deubiquitinating enzymes (DUBs) are a family of proteases that remove ubiquitin tags from proteins of interest undergoing proteasomal degradation. DUBs play several functional roles other than deubiquitination. One of the important roles of DUBs is regulation of tumor progression. Several reports have suggested that the DUB family members were highly-elevated in various cancer cells and tissues in different stages of cancer. These findings suggest that the DUBs could be used as drug targets in cancer therapeutics. In this review, we recapitulate the role of the DUB family members, including ubiquitinspecific protease, otubain protease, and important candidates from other family members. Our aim was to better understand the connection between DUB expression profiles and cancers to allow researchers to design inhibitors or gene therapies to improve diagnosis and prognosis of cancers.
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참고문헌 (98)
참고문헌 신청
Torre LA / 2012 / Global cancer statistics / CA Cancer J Clin 65:87~108
Li J / 1999 / Leukaemia disease genes : large-scale cloning and pathway predictions / Nat Genet 23:348~353
Hansen GM / 2000 / Genetic profile of insertion mutations in mouse leukemias and lymphomas / Genome Res 10:237~243
Fishel R / 1993 / The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer / Cell 75:1027~1038
Sharma A / 2018 / USP14regulates DNA damage repair by targeting RNF168-dependent ubiquitination / Autophagy 14:1976~1990
Li J / 1999 / Leukaemia disease genes : large-scale cloning and pathway predictions / Nat Genet 23:348~353
Hansen GM / 2000 / Genetic profile of insertion mutations in mouse leukemias and lymphomas / Genome Res 10:237~243
Fishel R / 1993 / The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer / Cell 75:1027~1038
Sharma A / 2018 / USP14regulates DNA damage repair by targeting RNF168-dependent ubiquitination / Autophagy 14:1976~1990
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