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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.9
- 수록면
- 135 - 144 (10page)
- DOI
- 10.7841/ksbbj.2019.34.3.135
이용수
초록· 키워드
오류제보하기
Sayuksan is four kinds of medical herbs which consist of Glycrrhizae uralensis Fischer, Paeonia lactiflora Pallas, Bupleurum falcatum Linne, and Poncirus trifoliata Rafinesqul. Sayuksan was co-cultured with Lactobacillus spp. strains and a Sacchar- omyces spp. strain, and fermented Sayuksan was extracted by ethyl acetate. As for 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) and [2,2"-azinobis (3-ethylbenzothiazoline-6-sulfonic acid)] (ABTS) free radical scavenging activities and Superoxide dismutase (SOD)-like activity as antioxidant activities, the extract of fermented Sayuksan had antioxidant activities at a lower concentration than that of Sayuksan, itself. The anticancer activity of fermented Sayuksan was confirmed in HCT 116 cells (human colon cancer cells), HepG2 cells (hepatoma cells), HeLa cells (cervical cancer cells), and MDAMB-231 cells (breast cancer cells). Fermented Sayuksan displayed anticancer activity against those four types of cancer cells at 500 μg/mL. HeLa cells showed a concentration-dependent decrease in viability after treatment with 10–500 μg/mL of the extract from fermented Sayuksan. HeLa cells whose proliferation was inhibited even at a low concentration of the extract from fermented Sayuksan were used to verify if the anticancer activity from fermented Sayuksan resulted from apoptosis. Apoptosis was detected by the poly ADP-ribose polymerase(PARP) and cleaved PARP expression patterns. The PARP protein cleaved at higher concentrations of the extract from both Sayuksan and fermented Sayuksan and induced apoptosis. Therefore, we conclude that inhibited proliferation of HeLa cells resulted from apoptosis induction by substances produced during fermentation.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHOD
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (39)
참고문헌 신청
신화석 / 2004 / 四逆散의 抗憂鬱效果 및 腦內 monoamine에 미치는 영향 / 대한본초학회지 19(2):71~82
Sun, Y. / 2009 / Si-Ni-San, a traditional Chinese prescription and its active ingredient glycyrrhizin ameliorate experimental colitis through regulating cytokine balance / J. Int. Immunopharmacol 9:1437~1443
Jung, S. Y. / 1996 / The effect of the water extract of Sayeuksan, and Shiho, Kamcho against CCl4-induced hepatotoxicity in rat / J. Dong Guk Oriental Med 5:53~77
Hubert, J. / 2008 / Effects of fermentation on the phytochemical composition and antioxidant properies of soy germ / Food Chem 109:709~721
박영자 / 2014 / 한약재발효액의 항생제 다제내성균에 대한 항균활성 및 항산화활성 / KSBB Journal 29(3):210~219
Sun, Y. / 2009 / Si-Ni-San, a traditional Chinese prescription and its active ingredient glycyrrhizin ameliorate experimental colitis through regulating cytokine balance / J. Int. Immunopharmacol 9:1437~1443
Jung, S. Y. / 1996 / The effect of the water extract of Sayeuksan, and Shiho, Kamcho against CCl4-induced hepatotoxicity in rat / J. Dong Guk Oriental Med 5:53~77
Hubert, J. / 2008 / Effects of fermentation on the phytochemical composition and antioxidant properies of soy germ / Food Chem 109:709~721
박영자 / 2014 / 한약재발효액의 항생제 다제내성균에 대한 항균활성 및 항산화활성 / KSBB Journal 29(3):210~219
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UCI(KEPA) : I410-ECN-0101-2019-470-001230363