지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.2
- 수록면
- 104 - 109 (6page)
- DOI
- https://doi.org/10.5483/BMBRep.2023-0225
이용수
초록· 키워드
오류제보하기
Gefitinib exerts anticancer effects on various types of cancer,such as lung, ovarian, breast, and colon cancers. However, thetherapeutic effects of gefitinib on cervical cancer and the un derlying mechanisms remain unclear. Thus, this study aimedto explore whether gefitinib can be used to treat cervical cancerand elucidate the underlying mechanisms. Results showed thatgefitinib induced a caspase-dependent apoptosis of HeLa cells,which consequently became round and detached from thesurface of the culture plate. Gefitinib induced the reorganiza tion of actin cytoskeleton and downregulated the expression ofp-FAK, integrin β1 and E-cadherin, which are important in cell extracellular matrix adhesion and cell-cell interaction, respecti vely. Moreover, gefitinib hindered cell reattachment and spread ing and suppressed interactions between detached cells insuspension, leading to poly (ADP-ribose) polymerase cleavage,a hallmark of apoptosis. It also induced detachment-inducedapoptosis (anoikis) in C33A cells, another cervical cancer cellline. Taken together, these results suggest that gefitinib triggersanoikis in cervical cancer cells. Our findings may serve as abasis for broadening the range of anticancer drugs used to treatcervical cancer.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Bee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner
BMB Reports
2020 .01
-
Co-Culturing Cancer Cells and Normal Cells in a Biochip under Electrical Stimulation
BioChip Journal
2018 .01
-
Deep Learning-Based Automated Analysis of NK Cell Cytotoxicity in Single Cancer Cell Arrays
BioChip Journal
2024 .09
-
3D Cancer Cell Chip for the Detection of Anticancer Drug Effects
한국고분자학회 학술대회 연구논문 초록집
2018 .04
-
Potential Anticancer Effect of Metasequoia glyptostroboides Extract by Inducing Apoptosis Pathway
한국생물공학회 학술대회
2021 .04
-
Measuring Mechanical Cell Properties of Paclitaxel-treated MCF-7 Cells in a Monolayer
한국생물공학회 학술대회
2021 .10
-
A Novel Hybrid Approach for Cervical Cancer Detection Using Multi-Stage CNN and Elastic Net Regression
한국통신학회 학술대회논문집
2024 .06
-
The Use of Normal Stem Cells and Cancer Stem Cells for Potential Anti-Cancer Therapeutic Strategy
조직공학과 재생의학
2018 .01
-
Survivin protects fused cancer cells from cell death
BMB Reports
2017 .07
-
Continuous Sorting and Washing of Cancer Cells from Blood Cells by Hydrophoresis
BioChip Journal
2016 .01
-
Development of culture strategies for stem cell maintenance and differentiation through regulation of cell behaviors
한국생물공학회 학술대회
2016 .04
-
Cancer cells undergoing epigenetic transition show short-term resistance and are transformed into cells with medium-term resistance by drug treatment
Experimental and Molecular Medicine
2020 .01
-
Development of Multi-functional NK Cell Coating Materials for Enhanced Cancer Immuno Therapy
한국생물공학회 학술대회
2020 .10
-
자궁경부암 세포를 위한 광학 모니터링 시스템의 설계 및 분석
전기학회논문지
2020 .11
-
Proteomic Studies of Cancer Stem Cells in HT-29 Human Colorectral Cancer Cell Line
한국생물공학회 학술대회
2015 .04
-
A Preliminary Study of the Proliferation Control System for Cervical Cancer Cells
INTERNATIONAL CONFERENCE ON FUTURE INFORMATION & COMMUNICATION ENGINEERING
2022 .01
-
Microsensor for Cancer Detection and MEMS Actuator for Cancer Therapy
Transactions on Electrical and Electronic Materials
2023 .02
-
An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib
Experimental and Molecular Medicine
2015 .01
-
Transgelin is Associated with Cisplatin-resistance in the CD133 (+) Subpopulation of HT-29 Human Colon Cancer Cell Line
한국생물공학회 학술대회
2015 .04
최근 본 자료
댓글(0)
0