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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 145 - 149 (5page)
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초록· 키워드
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Previously, we constructed a humanized antibody
(HuS10) that binds to the common a antigenic determinant
on the S protein of HBV. In this study, we evaluated
its HBV-neutralizing activity in chimpanzees. A study
chimpanzee was intravenously administered with a
single dose of HuS10, followed by intravenous challenge
with the adr subtype of HBV, while a control chimpanzee
was only challenged with the virus. The result
showed that the control chimpanzee was infected by
the virus, and thus serum HBV surface antigen
(HBsAg) became positive from the 14th to 20th week and
actively acquired serum anti-HBc and anti-HBs antibodies
appeared from the 19th and 23rd week, respectively.
However, in the case of the study chimpanzee,
serum HBsAg became positive from the 34th to 37th
week, while actively acquired serum anti-HBc and anti-
HBs antibodies appeared from the 37th and 40th week,
respectively, indicating that HuS10 neutralized the virus
in vivo and thus delayed the HBV infection. This
novel humanized antibody will be useful in the immunoprophylaxis
of HBV infection.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Beasley RP / 1983 / Prevention of perinatally transmitted hepatitis B virus infection with hepatitis B immune globulin and hepatitis B vaccine / Lancet 2 : 1099 ~ 102
Bhatnager PK / 1982 / Immune response to synthetic peptide analogues of HBsAg specific for the a detertminant / Proc Natl Acad Sci 79 : 4723 ~ 27
Bruce SA / 1995 / Mutations of some critical amino acids residues in the hepatitis B virus surface antigen / J Med Virol 46 : 157 ~ 61
Courouce AM / 1983 / Monoclonal antibodies to HBsAg: a study of their specificities for eight different HBsAg subtypes / Dev Biol Stand 54 : 527 ~ 34
Dreesman GR / 1982 / Antibody to hepatitis B surface antigen after a single inoculation of uncoupled synthetic HBsAg peptides / Nature (London) 295 : 158 ~ 60
Bhatnager PK / 1982 / Immune response to synthetic peptide analogues of HBsAg specific for the a detertminant / Proc Natl Acad Sci 79 : 4723 ~ 27
Bruce SA / 1995 / Mutations of some critical amino acids residues in the hepatitis B virus surface antigen / J Med Virol 46 : 157 ~ 61
Courouce AM / 1983 / Monoclonal antibodies to HBsAg: a study of their specificities for eight different HBsAg subtypes / Dev Biol Stand 54 : 527 ~ 34
Dreesman GR / 1982 / Antibody to hepatitis B surface antigen after a single inoculation of uncoupled synthetic HBsAg peptides / Nature (London) 295 : 158 ~ 60
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