지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Trigeminal primary afferents expressing P2X3 or transient receptor potential vanilloid 1 (TRPV1) are involved in the
transmission of nociceptive information. In order to characterize P2X3- and TRPV1-immunopositive neurons in the trigeminal
ganglion (TG) and trigeminal caudal nucleus (Vc), we performed immunofluorescence experiments using anti-
P2X3 and anti-TRPV1 antisera and a morphometric analysis.
77.4% (1,401/1,801) of all the P2X3-postive neurons coexpressed TRPV1 and 51.9% (1,401/2,698) of all the TRPV1-
immunopositive neurons also costained for P2X3 in the TG. Immunoreactivity for both P2X3 and TRPV1 were present in
medium-sized neurons but not in small- and large-sized neurons. P2X3- and/or TRPV1-immunopositive fibers were observed
in the primary afferents and their associated axons in the Vc. These fibers and terminals were distributed in the
superficial lamina of Vc: P2X3-immunopositive fibers and terminals were distributed in the lamina I and II, expecially in
the inner part of lamina II (lamina IIi), whereas TRPV1-immunopositive ones were densely detected in the lamina I and
outer part of lamina II (lamina IIo). Immunopositive fibers and terminals for both P2X3 and TRPV1 were observed on the
border between lamina IIi and IIo.
These results suggest that terminals coexpressing P2X3 and TRPV1 are involved in specific roles in the transmission
and processing of orofacial nociceptive information.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ambalavanar R / 2005 / Trigeminal P2X3 receptor expression differs from dorsal root ganglion and is modulated by deep tissue inflammation / Pain 117 : 280 ~ 291
Aoki Y / 2003 / P2X3-immunoreactive primary sensory neurons innervating lumbar intervertebral disc in rats / Brain Res 989 : 214 ~ 220
Bradbury EJ / 1998 / The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor / Mol Cell Neurosci 12 : 256 ~ 268
Burnstock G / 1990 / Local mechanisms of blood flow control by perivascular nerves and endothelium / J Hypertens Suppl 8 : S95 ~ S106
Burnstock G / 1996 / A unifying purinergic hypothesis for the initiation of pain / Lancet 347 : 1604 ~ 1605
Aoki Y / 2003 / P2X3-immunoreactive primary sensory neurons innervating lumbar intervertebral disc in rats / Brain Res 989 : 214 ~ 220
Bradbury EJ / 1998 / The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor / Mol Cell Neurosci 12 : 256 ~ 268
Burnstock G / 1990 / Local mechanisms of blood flow control by perivascular nerves and endothelium / J Hypertens Suppl 8 : S95 ~ S106
Burnstock G / 1996 / A unifying purinergic hypothesis for the initiation of pain / Lancet 347 : 1604 ~ 1605
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