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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1997.1
- 수록면
- 11 - 19 (9page)
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초록· 키워드
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The use of therapeutic ultrasound(US) in humans with malignant neoplasms has beencontraindicated in physical therapy practice. Some studies have shown that results afterapplication of US differ according to tumor type and penetratjon depth. The purposes ofthis study were to determine the effects of US on melanoma in mice and to determinetreatment dosage. Twenty-four female C57BL/6 mice, age 8 weeks. The right flank of 떠lmice was shaved, and a 0.1 ml suspension of cells was injected subcutaneously into thea띠mals ’ right flank. In this study, 24 subjects were randomly divided into three groups:experimental group 1<n=8), experimental group 2(n=8), control group(n=8). In theexperil)1ental group 1, animals received continuous 3 MHZ US treatment, administered at 2.0W!cm‘ for five minutes. In experime.ntal group 2, animals received continuous 3 MHz UStreatment, administered at 1.0 W!cm" for 5 minutes. The control group received the samehandling as other experimental groups, including rodent chow, water, US gel application but US head pressure without the power turned on. After 10 days treatment, all mice werekilled with a potassium solution. Tumors were excised and weighed on an electrical balanceand fixed in a 10% neutral buffered formalin solution. Tumor weights were smaller inexperimental group 2<0.3838 g) than in the control group<O.6275 g). Tumor weights of theexperimental group 1<0.015 g) were smaller than those of experimental group 2. Continuoustherapeutic US decreased the weight of subcutaneous melanoma tumors in mice. Thetreatment dosage(2.0 W/cm2) we suggest was more effective than earlier studies ondecreasing tumor size with ultrasound.
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