지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 877 - 886 (10page)
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초록· 키워드
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Over the past three decades, a large number of genetic studies have been aimed at finding genetic variants associated with the risk of asthma, applying various genetic and genomic approaches including linkage analysis, candidate gene polymorphism studies, and genome-wide association studies (GWAS). However, contrary to generalexpectation, even single nucleotide polymorphisms (SNPs) discovered by GWAS failed to fully explain the heritability of asthma. Thus, application of rare allelepolymorphisms in well defined phenotypes and clarification of environmental factors have been suggested to overcome the problem of ‘missing’ heritability. Such factors include allergens, cigarette smoke, air pollutants, and infectious agents duringpre- and post-natal periods. The first and simplest interaction between a gene and the environment is a candidate interaction of both a well known gene and environmentalfactor in a direct physical or chemical interaction such as between CD14 and endotoxin or between HLA and allergens. Several GWAS have found environmentalinteractions with occupational asthma, aspirin exacerbated respiratory disease,tobacco smoke-related airway dysfunction, and farm-related atopic diseases. As one of the mechanisms behind gene-environment interaction is epigenetics, a few studies on DNA CpG methylation have been reported on subphenotypes of asthma, pitching the exciting idea that it may be possible to intervene at the junction between the genome and the environment. Epigenetic studies are starting to include data from clinical samples, which will make them another powerful tool for researchon gene-environment interactions in asthma.
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참고문헌 (69)
참고문헌 신청
Haldane JBS / 1938 / Heredity and politics / George Allen & Unwin Ltd Pblisher
Wu Huiyan / 2014 / The Importance of Allergen Avoidance in High Risk Infants and Sensitized Patients: A Meta-analysis Study / Allergy, Asthma & Immunology Research 6(6):525~534
Peden D / 2010 / Environmental and occupational allergies / J Allergy Clin Immunol 125(2 Suppl 2):S150~s160
von Mutius E / 2009 / Gene-environment interactions in asthma / J Allergy Clin Immunol 123:3~11
박혜정 / 2014 / Changes in Allergen Sensitization Over The Last 30 Years in Korea Respiratory Allergic Patients: A Single-Center / Allergy, Asthma & Immunology Research 6(5):434~443
Wu Huiyan / 2014 / The Importance of Allergen Avoidance in High Risk Infants and Sensitized Patients: A Meta-analysis Study / Allergy, Asthma & Immunology Research 6(6):525~534
Peden D / 2010 / Environmental and occupational allergies / J Allergy Clin Immunol 125(2 Suppl 2):S150~s160
von Mutius E / 2009 / Gene-environment interactions in asthma / J Allergy Clin Immunol 123:3~11
박혜정 / 2014 / Changes in Allergen Sensitization Over The Last 30 Years in Korea Respiratory Allergic Patients: A Single-Center / Allergy, Asthma & Immunology Research 6(5):434~443
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