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This study was carried out to investigate the antioxidative and antitumor activities of Saussurea lappa for the purpose of developing a functional food. The methanol extract of Saussurea lappa was fractionated with five solvents(hexane, chloroform, EtOAc, BuOH, water) and examined antioxidative activities and xanthine oxidase inhibitory activity in addition to growth inhibitory activity of human cancer cell(HT-29, SNU-1, HeLa). Total phenol compounds contents were higher in EtOAC fraction than other fractions. Also, electron donating ability was over 90% at 500㎍/㎖ (93.1%) and 1000㎍/㎖ (94.3%). Hexane fraction revealed stronger nitrite scavenging ability than positive control(ascorbic acid) and its abilities were 22.4% and 42.8% at 500㎍/㎖ and 1000㎍/㎖, respectively. Xanthine oxidase inhibitory activity had similar tendency to electron donating ability. EtOAc fraction showed high inhibition to xanthien oxidase activities at 500㎍/㎖ (81.9%) and 1000㎍/㎖ (90.4%). In antitumor activity test, hexane fraction exhibited potent growth inhibition activity against HT-29, SNU-1 and HeLa cells. Therefore, we believe that Saussurea lappa can be developed into functional food with antioxidant activity. Additional studies are required for the hexane and chloroform fractions of Saussurea lappa to develop them into therapeutic supplements for stomach cancer, colon cancer, and cervical cancer.
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참고문헌 (26)
참고문헌 신청
Blois, M. S. / 1958 / Antioxidant determination by the use of a stable free radical / Nature 181 : 1199 ~ 1200
Branen, A. L. / 1975 / Toxicological and biochemistry of butylated hydroxyanisole and butylated hydroxytolune / JAOCS 52 : 59 ~ 65
Carmichael, J. / 1987 / Evaluation of tetrazolium-based semiautomated colorimetic assay / Assesment of chemosensitivity testing 47 : 936 ~
Choi, W. S. / 2002 / Antioxidative and cytotoxicity activities of compounds isolated from Korean Phus verniciflua S / Korean Soc. Agric. Chem. Biotechnol 45 (3) : 168 ~ 172
Duke, E. J. / 1973 / Characterization of alternative molecular forms of xanthine oxidase in the mouse / J. Biochem 131 : 187 ~ 194
Branen, A. L. / 1975 / Toxicological and biochemistry of butylated hydroxyanisole and butylated hydroxytolune / JAOCS 52 : 59 ~ 65
Carmichael, J. / 1987 / Evaluation of tetrazolium-based semiautomated colorimetic assay / Assesment of chemosensitivity testing 47 : 936 ~
Choi, W. S. / 2002 / Antioxidative and cytotoxicity activities of compounds isolated from Korean Phus verniciflua S / Korean Soc. Agric. Chem. Biotechnol 45 (3) : 168 ~ 172
Duke, E. J. / 1973 / Characterization of alternative molecular forms of xanthine oxidase in the mouse / J. Biochem 131 : 187 ~ 194
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