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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Saussurea lappa Clarke is a well-known transitional medicine in Asia including Korea, China and Japan. It has been reported that Clarke has diverse effects such as anti-viral, anti-inflammatory, anti-cancer in human gastric cells and human prostate cancer cells. However, the anti-cancer effects and the mechanism of actions of Saussurea lappa Clarke are still unknown in breast cancer. In this study, we observed that Saussurea lappa Clarke inhibits the cell growth in a dose- and time-dependent manner in highly-metastatic MDA-MB-231 breast cancer cells. In order to examine whether Saussurea lappa Clarke suppresses cell growth inducing apoptosis cell death or cell cycle arrest, we analyzed DNA contents and cell cycle distribution using a flow cytometer and western blotting in MDA-MB-231 cells. We suggest that Saussurea lappa Clarke dose not induced apoptosis and induced G2/M phase cell cycle arrest. Moreover, Saussurea lappa Clarke also decreased the expression level of metastasis-angiogenesis releated protein such as VEGF. However, dose not changed the expression level of metastasis related protease MMP-1 in highly-metastatic MDA-MB-231 breast cancer cells. Therefore, Saussurea lappa Clarke might be good and useful chemotherapy agent highly-metastatic breast cancer patients.
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참고문헌 (35)
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1. [학술지(정기간행물)] - Edwards, B.K. / 2005 / Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment / J. Natl. Cancer Inst 97 (19) : 1407 ~ 1427
2. [학술지(정기간행물)] - Park, S. / 2008 / Aetiology of cancer in asia / Asian Pac. J. Cancer. Prev 9 (3) : 371 ~ 380
3. [학술지(정기간행물)] - Block, K.I. / 2009 / Survival impact of integrative cancer care in advanced metastatic breast cancer / Breast J 15 (4) : 357 ~ 366
4. [학술지(정기간행물)] - Gupta, G.P. / 2005 / Identifying site-specific metastasis genes and functions. Cold Spring Harb / Symp. Quant. Biol 70 : 149 ~ 158
5. [학술지(정기간행물)] - Shishodia, S. / 2003 / Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of Ikapp a Balpha kinase and p65 phosphorylation: Correlation with down-regulation of cyclooxy genase 2, matrix metalloproteinase 9, and cyclin D1 / Cancer Res 63 (15) : 4375 ~ 4383
2. [학술지(정기간행물)] - Park, S. / 2008 / Aetiology of cancer in asia / Asian Pac. J. Cancer. Prev 9 (3) : 371 ~ 380
3. [학술지(정기간행물)] - Block, K.I. / 2009 / Survival impact of integrative cancer care in advanced metastatic breast cancer / Breast J 15 (4) : 357 ~ 366
4. [학술지(정기간행물)] - Gupta, G.P. / 2005 / Identifying site-specific metastasis genes and functions. Cold Spring Harb / Symp. Quant. Biol 70 : 149 ~ 158
5. [학술지(정기간행물)] - Shishodia, S. / 2003 / Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of Ikapp a Balpha kinase and p65 phosphorylation: Correlation with down-regulation of cyclooxy genase 2, matrix metalloproteinase 9, and cyclin D1 / Cancer Res 63 (15) : 4375 ~ 4383
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