지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Saussurea lappa (SL) and major compounds, sesquiterpene lactones, have been suggested to possess various biological effects, including anti-tumor, anti-ulcer, anti-inflammatory, anti-viral and cardiotonic activities. Therefore, the ethanol extract of Saussurea lappa root (ESL) is studied for the mechanism of its action in apoptotic pathway. ESL-treated cells manifested nuclear condensation, and fragmentation. ESL also triggered the mitochondrial apoptotic pathway, as indicated by a change in Bax/Bcl2 ratio and caspase-9/-3 activation. ESL induced p38 MAPK/JNK, p53, and ASK1 phosphorylation. ROS scavenger reversed ESL-induced apoptotic cell death via inhibition of caspase-3 and p38 MAPK/JNK phosphorylation. These results suggest that ESL induced apoptosis in HepG2 cells through the ROS-p38/JNK pathway.
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참고문헌 (27)
참고문헌 신청
Mountz, J. D. / 1995 / Regulation of apoptosis in immune cells / J. Clin. Immunol 15:1
Woo, M. / 1998 / Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes / Genes Dev 12:806
Kaufmann, S. H. / 1993 / Specific proteolytic cleavage of poly(ADPribose) polymerase: an early marker of chemotherapy-induced apoptosis / Cancer Res 53:3976
An, B. / 1996 / Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate / Cancer Res 56:438
Hwang, S. G. / 2002 / Anticancer-drug-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin / Leuk. Res 26:863
Woo, M. / 1998 / Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes / Genes Dev 12:806
Kaufmann, S. H. / 1993 / Specific proteolytic cleavage of poly(ADPribose) polymerase: an early marker of chemotherapy-induced apoptosis / Cancer Res 53:3976
An, B. / 1996 / Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate / Cancer Res 56:438
Hwang, S. G. / 2002 / Anticancer-drug-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin / Leuk. Res 26:863
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