지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 66 - 70 (5page)
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초록· 키워드
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Background: Various therapeutic options, including surgery, electrocautery, cryotherapy, 5-fluorouracil treatment, laser therapy, radiotherapy, photodynamic therapy, and interferon- α/γ injection, have been employed to treat vulvar intraepithelial neoplasia (VIN) with varying degrees of success.
To truly cure VIN, human papillomavirus elimination is considered important. Objective: To investigate the efficacy of 5% imiquimod cream used to treat VIN in Korean patients Methods: We performed a prospective, uncontrolled, observational study. Nine patients with histologically confirmed VIN applied 5% imiquimod cream to their vulvar lesions three to five times a week until a clinical response was apparent. All lesions were photo-documented, and therapeutic efficacy was assessed in terms of local adverse effects lesion number, size, and hyperpigmentation. Results: The mean treatment duration was 30.2 months, and the median follow-up period after therapy completion was 30 months.
Of the nine patients recruited, six (66.6%) experienced complete responses (CR) or partial responses (PR). Hyperpigmented patches in the VIN lesions were evident in five subjects (55.6%), and all experienced either CR or PR. Only three patients (33.3%) suffered from local adverse effects, which were relieved after temporary suspension of therapy, and better outcomes were attained ultimately. Conclusion: The imiquimod cream was more efficacious when used to treat VIN of the hyperpigmented type compared with lesions lacking pigmentation. The unifocal nature of a lesion and the development of local adverse effects are useful factors when imiquimod cream is prescribed. However, although the cream is convenient and effective, regional resistance may develop, and close follow-up is essential because VIN may become malignant.
목차
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참고문헌 (17)
참고문헌 신청
Alessi SS / 2009 / Treatment of cutaneous tumors with topical 5% imiquimod cream / Clinics (Sao Paulo) 64 : 961 ~ 966
Frega A / 2013 / Imiquimod 5% cream versus cold knife excision for treatment of VIN 2/3: a five-year follow-up / Eur Rev Med Pharmacol Sci 17 : 936 ~ 940
Hillemanns P / 2000 / Photodynamic therapy of vulvar intraepithelial neoplasia using 5-aminolevulinic acid / Int J Cancer 85 : 649 ~ 653
Le T / 2007 / Final results of a phase 2 study using continuous 5% Imiquimod cream application in the primary treatment of high-grade vulva intraepithelial neoplasia / Gynec
Leonard B / 2014 / A clinical and pathological overview of vulvar condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma / Biomed Res Int 2014 : 480573
Frega A / 2013 / Imiquimod 5% cream versus cold knife excision for treatment of VIN 2/3: a five-year follow-up / Eur Rev Med Pharmacol Sci 17 : 936 ~ 940
Hillemanns P / 2000 / Photodynamic therapy of vulvar intraepithelial neoplasia using 5-aminolevulinic acid / Int J Cancer 85 : 649 ~ 653
Le T / 2007 / Final results of a phase 2 study using continuous 5% Imiquimod cream application in the primary treatment of high-grade vulva intraepithelial neoplasia / Gynec
Leonard B / 2014 / A clinical and pathological overview of vulvar condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma / Biomed Res Int 2014 : 480573
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