지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Developmentally regulated GTP-binding protein 2 (DRG2) is a type of GTP-binding protein that plays an essential role in cell growth and differentiation, but its role in certain diseases remains unknown. A previous study revealed that DRG2 inhibits nuclear factor kappa B (NF-kB) function in macrophages and prevents T helper 17 cell (Th17) differentiation; this suggests possible DRG2 involvement in the pathogenesis and clinical phenotype of psoriasis.
Objective: We aimed to investigate the relationship between DRG2 expression in mice and psoriatic lesions.
Methods: Psoriasis was induced by applying imiquimod cream for 6 days to the shaved backs of C57BL/6 (WT mice) and DRG2 knock-out mice (KO mice). During the following 15 days, clinical improvements, histopathological changes, and IL-10 expression in the two groups were compared.
Results: In WT mice, lesions began to improve after 6 days, and almost all lesions had resolved by day 12. In contrast, inflammation persisted in KO mice until day 15. Clinical indicators and histopathological findings followed a similar pattern.
IL-10 was significantly overexpressed in WT mice, while minimally expressed in KO mice.
Conclusion: When imiquimod was applied to KO mice, psoriasis-like lesions were induced because of the absence of DRG2.
This showed the relevance of DRG2 in the pathogenesis of psoriasis and suggested that DRG2 knockout mice serve as a novel psoriasis model that compensates for the shortcomings of the existing one.
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