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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
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Background: Angioimmunoblastic T-cell lymphoma (AITL)
is a complex lymphoproliferative disorder and often mimics
a viral infection with frequent skin involvement. Epstein-Barr
virus (EBV) and human herpes virus (HHV)-6 are reported to
be associated with AITL, but there are conflicting results.
Objective: We evaluated the association of EBV and HHV-6
with AITL. Methods: We reviewed the clinical, histological
and immunophenotypical features of 19 cases of AITL.
Among them, 11 lymph node biopsies of AITL were
examined for HHV-6, -7, and -8 by polymerase chain
reaction (PCR) using virus-specific primers. In situ hybridization
of EBV early region RNA (EBER) was performed and
T cell receptor (TCR) gene rearrangement was also
investigated in some cases. Results: Among these 19 cases,
maculopapular, plaque or nodular skin lesions accompanied
AITL in 12 cases. Clonal TCR gene rearrangement
was seen in 8/9 cases tested. EBER in situ hybridization was
positive in 8 cases (57.1%). Among 7 cases with skin
biopsies, five cases were consistent with cutaneous involvement
of AITL, 1 case was a drug eruption, and the other case
was Kaposi's sarcoma. Except a HHV-8 (＋) case who also
had Kaposi's sarcoma, all of these cases were negative for
HHV-6, -7 and -8. Conclusion: Skin manifestation seems to
be a cardinal component of AITL, be it in the context of
presentation, progression or recurrent disease. Recognition
of clinicopathological features of skin lesions in AITL as
diagnostic clues should be stressed among dermatologists.
The lack of HHV-6, -7 and -8 in lymph node biopsy of AITL
argues against a pathogenic role for HHVs in AITL.
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참고문헌 (15)
참고문헌 신청
Bernstein JE / 1979 / Cutaneous manifestations of angioimmunoblastic lymphadenopathy / J Am Acad Dermatol 1 : 227 ~ 232
Brown HA / 2001 / Cutaneous involvement by angioimmunoblastic T-cell lymphoma with remarkable heterogeneous Epstein-Barr virus expression / J Cutan Pathol 28 : 432 ~ 438
Daibata M / 1997 / Angioimmunoblastic lymphadenopathy with disseminated human herpesvirus 6 infection in a patient with acute myeloblastic leukemia / Leukemia 11 : 882 ~ 885
Dogan A / 2003 / Angioimmunoblastic T-cell lymphoma / Br J Haematol 121 : 681 ~ 691
Jaffe ES / 2001 / World Health Organization classification of tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissues / IARC Press
Brown HA / 2001 / Cutaneous involvement by angioimmunoblastic T-cell lymphoma with remarkable heterogeneous Epstein-Barr virus expression / J Cutan Pathol 28 : 432 ~ 438
Daibata M / 1997 / Angioimmunoblastic lymphadenopathy with disseminated human herpesvirus 6 infection in a patient with acute myeloblastic leukemia / Leukemia 11 : 882 ~ 885
Dogan A / 2003 / Angioimmunoblastic T-cell lymphoma / Br J Haematol 121 : 681 ~ 691
Jaffe ES / 2001 / World Health Organization classification of tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissues / IARC Press
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