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자료유형
학술저널
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저널정보
대한소아감염학회 Pediatric Infection and Vaccine Pediatric Infection and Vaccine 제12권 제2호
발행연도
2005.1
수록면
108 - 113 (6page)

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Pur po se : Human herpsevirus 8(HHV-8), a gamma herpsevirus, was initially identified from Kaposi sarcoma(KS) lesions and has been known to be associated with several malignancies including Kaposi sarcoma. HHV-8 seroprevalence is variable by different geographic areas and populations. The prevalence of HHV 8 infection in Korean children is unclear. So, we investigated the prevalence of HHV-8 specific antibodies in healthy children in Seoul, Korea. Methods : Sera were obtained from 112 children(age 1∼15 years, 64 males and 48 females) who visited our hospital for routine health checkup and used for investigating seroprevalence of anti-HHV-8 antibodies. An indirect immunofluorescent assay was used to detect the IgG antibodies to the lytic viral antigen(Biotrin, Dublin, Ireland). A peptide mix ELISA kit was used to detect the IgG antibodies to peptides specific for HHV-8 open reading frame (ORF)(Biotrin, Dublin, Ireland). Results : Of 112 children, 4 children younger than 6 years of age were seropositive to HHV-8[all 4(3.5%) were positive by IFA and 2(1.8%) were positive by ELISA]. Co nclusio n : These results suggest that the prevalence of antibody to HHV 8 in children in Korea is very low.

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