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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 562 - 565 (4page)
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Background: The causative agents of leprosy are the well-known Mycobacterium leprae and the newly discovered Mycobacterium lepromatosis. This agent was found in 2008, and it was found to be the cause of diffuse lepromatous leprosy in two Mexican patients. Objective: The objective of this work was to determine if M. leprae and M. lepromatosis were present in formalin-fixed and paraffin- embedded skin samples from cases from different regions in Mexico. Methods: A total of 41 skin samples were obtained from 11 states of Mexico. All patients’ samples were diagnosed by clinical and histopathological analyses. Total DNA was isolated using a Qiagen-DNeasy blood and tissue kit and molecular identification was achieved by two semi-nested polymerase chain reactions. Results: The 41 patient included 33 samples from men and 8 samples from women; 29 samples were polymerase chain reaction (PCR)-positive to Mycobacterium and 12 samples were PCR-negative. From those 29 samples, 13 were PCR-positive to M. leprae, 8 to M. lepromatosis and 8 were positive to both species. The histopathological diagnosis included; Nodular lepromatous leprosy (NLL); Diffuse lepromatous leprosy (DLL); and Borderline leprosy (BL). The 29 PCR-positive samples were classified as follow: 14 NLL, 4 DLL, and 11 BL. In the 12 samples negative to Mycobacterium, 7 showed the NLL, 2 DLL and 3 BL. Conclusion: These findings add evidence to the M. leprae and M. lepromatous distribution, clinical forms and participation of dual infections in Mexico.
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참고문헌 (21)
참고문헌 신청
Lupi O / 2006 / Tropical dermatology: bacterial tropical diseases / J Am Acad Dermatol 54:559~578
Han XY / 2008 / A new mycobacterium species causing diffuse lepromatous leprosy / Am J Clin Pathol 130:856~864
World Health Organization / 2016 / Global leprosy update, 2015: time for action, accountability and inclusion / Wkly Epidemiol Rec 91:405~420
2016 / Secretaria de la Salud. Direccion General de Epidemiologia [Internet]
Han XY / 2009 / Comparative sequence analysis of mycobacterium leprae and the new leprosy-causing mycobacterium lepromatosis / J Bacteriol 191:6067~6074
Han XY / 2008 / A new mycobacterium species causing diffuse lepromatous leprosy / Am J Clin Pathol 130:856~864
World Health Organization / 2016 / Global leprosy update, 2015: time for action, accountability and inclusion / Wkly Epidemiol Rec 91:405~420
2016 / Secretaria de la Salud. Direccion General de Epidemiologia [Internet]
Han XY / 2009 / Comparative sequence analysis of mycobacterium leprae and the new leprosy-causing mycobacterium lepromatosis / J Bacteriol 191:6067~6074
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